SLC22A13 - solute carrier family 22 member 13 Gene

Homo sapiens

Also known as OAT10; OCTL1; OCTL3; ORCTL3; ORCTL-3

Gene ID: 9390 | Gene type: protein coding

About SLC22A13

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,265,812-38,278,757 (from NCBI)

This gene has 3 transcripts (splice variants), 325 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 6.8).

Summary

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

SLC22A13 Products(1)

mRNA	Protein	Name
NM_004256.4	NP_004247.2	solute carrier family 22 member 13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nicotinate transmembrane transporter activity	EXP EXP: Inferred from Experiment	18411268	GOA
enables nicotinate transmembrane transporter activity	IDA IDA: Inferred from direct assay	18411268	GOA
enables urate transmembrane transporter activity	IDA IDA: Inferred from direct assay	18411268	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of fatty acid metabolic process	IDA IDA: Inferred from direct assay	24769897	GOA
involved in nicotinate transport	IDA IDA: Inferred from direct assay	18411268	GOA
involved in positive regulation of T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	19282870	GOA
involved in urate transport	IDA IDA: Inferred from direct assay	18411268	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19282870	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18411268	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19282870	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19282870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A13 Protein Structure

Sugar_tr

0
100
200
300
400
500
551 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 13

organic anion transporter 10

Related Diseases

Diseases

Alias

Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To	Uric Acid Urolithiasis
Uric Acid Nephrolithiasis	UAN
Acute Urate Nephropathy	Urolithiasis, Uric Acid
Urolithiasis, Uric Acid, Susceptibility To	Uric Acid Renal Calculus

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Renal Glucosuria

Renal Glycosuria	Familial Renal Glucosuria
GLYS	Glys1
Glycosuria, Renal	Glucosuria, Renal
Renal Diabetes	Familial Renal Glycosuria
Sglt2 Deficiency	Gly
Diabetes Renal

Brown-Vialetto-Van Laere Syndrome 2

BVVLS2	Rfvt3-Related Riboflavin Transporter Deficiency
Rtd3	Riboflavin Transporter Deficiency 3
Brown-Vialetto-Van Laere Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13066	SLC22A13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC22A13	VGNC	VGNC:77593
Rattus norvegicus	SLC22A13	RGD	RGD:1583222
Canis familiaris	SLC22A13	VGNC	VGNC:46274
Felis catus	SLC22A13	VGNC	VGNC:68653
Mus musculus	SLC22A13	MGD	MGI:2143107
Bos taurus	SLC22A13	VGNC	VGNC:34721

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