TMPRSS11D - transmembrane serine protease 11D Gene

Homo sapiens

Also known as ASP; HAT

Gene ID: 9407 | Gene type: protein coding

About TMPRSS11D

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:67,820,876-67,884,002 (from NCBI)

This gene has 8 transcripts (splice variants), 534 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 30.2).

Summary

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, Enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to Other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with Other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]

TMPRSS11D Products(1)

mRNA	Protein	Name
NM_004262.3	NP_004253.1	transmembrane protease serine 11D

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	24227843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS11D Protein Structure

SEA

Trypsin

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

transmembrane protease serine 11D

adrenal secretory serine protease

TMPRSS11D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMPRSS11D	O60235	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	TMPRSS11D	O60235	SGTA	Homo sapiens	O43765	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMPRSS11D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76680	TMPRSS11D Protein, Human (HEK293, His)	O60235/NP_004253.1 (I187-I418)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 27

DFNB27	Autosomal Recessive Nonsyndromic Deafness 27
Autosomal Recessive Deafness 27

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Deafness, Autosomal Dominant 27

DFNA27	Autosomal Dominant Nonsyndromic Deafness 27
Autosomal Dominant Deafness 27	Deafness, Autosomal Dominant, 27

Intellectual Developmental Disorder, X-Linked 108

MRX108	X-Linked Intellectual Developmental Disorder 108
Mental Retardation, X-Linked 108	Mental Retardation, X-Linked, Type 108

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14765	TMPRSS11D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMPRSS11D	VGNC	VGNC:107206
Felis catus	TMPRSS11D	VGNC	VGNC:66382
Mus musculus	TMPRSS11D	MGD	MGI:2385221
Bos taurus	TMPRSS11D	VGNC	VGNC:55082
Canis familiaris	TMPRSS11D	VGNC	VGNC:47629
Rattus norvegicus	TMPRSS11D	RGD	RGD:620654
Others	TMPRSS11D	NCBI

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