TP53INP1 - tumor protein p53 inducible nuclear protein 1 Gene

Homo sapiens

Also known as SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B

Gene ID: 94241 | Gene type: protein coding

About TP53INP1

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,925,972-94,949,378 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 25.0), testis (RPKM 21.8) and 25 other tissues.

Summary

Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TP53INP1 Products(2)

mRNA	Protein	Name
NM_001135733.2	NP_001129205.1	tumor protein p53-inducible nuclear protein 1 isoform b
NM_033285.4	NP_150601.1	tumor protein p53-inducible nuclear protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22421968	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagic cell death	IMP IMP: Inferred from mutant phenotype	22421968	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22470510	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22421968	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	22421968	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22470510	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22470510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53INP1 Protein Structure

DOR

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

tumor protein p53-inducible nuclear protein 1

p53-dependent damage-inducible nuclear protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14920	TP53INP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TP53INP1	VGNC	VGNC:66465
Bos taurus	TP53INP1	VGNC	VGNC:36236
Mus musculus	TP53INP1	MGD	MGI:1926609
Rattus norvegicus	TP53INP1	RGD	RGD:631423
Canis familiaris	TP53INP1	VGNC	VGNC:47725

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