TP53INP1 - tumor protein p53 inducible nuclear protein 1 Gene

Homo sapiens

Also known as SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B

Gene ID: 94241 | Gene type: protein coding

About TP53INP1

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,925,972-94,949,378 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 25.0), testis (RPKM 21.8) and 25 other tissues.

Summary

Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TP53INP1 Products(2)

mRNA	Protein	Name
NM_001135733.2	NP_001129205.1	tumor protein p53-inducible nuclear protein 1 isoform b
NM_033285.4	NP_150601.1	tumor protein p53-inducible nuclear protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22421968	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagic cell death	IMP IMP: Inferred from mutant phenotype	22421968	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22470510	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22421968	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	22421968	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22470510	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22470510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53INP1 Protein Structure

DOR

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

tumor protein p53-inducible nuclear protein 1

p53-dependent damage-inducible nuclear protein 1

TP53INP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TP53INP1	Q96A56	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H Prey Pooling	32296183
Intra	TP53INP1	Q96A56	MAP1LC3C	Homo sapiens	Q9BXW4	Validated Y2H	32296183
Intra	TP53INP1	Q96A56	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H Array	32296183
Intra	TP53INP1	Q96A56	GABARAP	Homo sapiens	O95166	Y2H Prey Pooling	32296183
Intra	TP53INP1	Q96A56	GABARAP	Homo sapiens	O95166	Y2H Array	32296183
Intra	TP53INP1	Q96A56	GABARAPL2	Homo sapiens	P60520	Y2H Prey Pooling	32296183
Intra	TP53INP1	Q96A56	GABARAPL2	Homo sapiens	P60520	Y2H Array	32296183
Intra	TP53INP1	Q96A56	GABARAPL1	Homo sapiens	Q9H0R8	Y2H Prey Pooling	32296183
Intra	TP53INP1	Q96A56	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	TP53INP1	Q96A56	GABARAPL1	Homo sapiens	Q9H0R8	Y2H Array	32296183
Intra	TP53INP1	Q96A56	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14920	TP53INP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TP53INP1	VGNC	VGNC:66465
Bos taurus	TP53INP1	VGNC	VGNC:36236
Mus musculus	TP53INP1	MGD	MGI:1926609
Rattus norvegicus	TP53INP1	RGD	RGD:631423
Canis familiaris	TP53INP1	VGNC	VGNC:47725

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