AKAP7 - A-kinase anchoring protein 7 Gene

Homo sapiens

Also known as AKAP15; AKAP18

Gene ID: 9465 | Gene type: protein coding

About AKAP7

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,125,627-131,283,532 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 12.1), duodenum (RPKM 4.2) and 23 other tissues.

Summary

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the Enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

AKAP7 Products(9)

mRNA	Protein	Name
NM_001376570.1	NP_001363499.1	A-kinase anchoring protein 7 isoform 4
NM_001387860.1	NP_001374789.1	A-kinase anchoring protein 7 isoform 5
NM_001387861.1	NP_001374790.1	A-kinase anchoring protein 7 isoform 6
NM_001387862.1	NP_001374791.1	A-kinase anchoring protein 7 isoform 7
NM_001387863.1	NP_001374792.1	A-kinase anchoring protein 7 isoform 8
NM_001387864.1	NP_001374793.1	A-kinase anchoring protein 7 isoform 9
NM_004842.4	NP_004833.1	A-kinase anchoring protein 7 isoform alpha
NM_016377.4	NP_057461.2	A-kinase anchoring protein 7 isoform gamma
NM_138633.3	NP_619539.1	A-kinase anchoring protein 7 isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17244820	GOA
enables protein kinase A binding	IDA IDA: Inferred from direct assay	9545239	GOA
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	25097019	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	11299204	GOA
involved in positive regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	11299204	GOA
involved in positive regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	11299204	GOA
involved in regulation of membrane repolarization	IDA IDA: Inferred from direct assay	11299204	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10613906	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10613906	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	10613906	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25097019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP7 Protein Structure

AKAP7_NLS

AKAP7_RIRII_bdg

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

A-kinase anchoring protein 7

A kinase (PRKA) anchor protein 7

Related Diseases

Diseases

Alias

Familial Febrile Seizures

Familial Febrile Convulsions	Feb
Febrile Seizures, Familial

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00522	AKAP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKAP7	RGD	RGD:1303071
Canis familiaris	AKAP7	VGNC	VGNC:37760
Bos taurus	AKAP7	VGNC	VGNC:25788
Macaca mulatta	AKAP7	VGNC	VGNC:69772
Mus musculus	AKAP7	MGD	MGI:1859150
Felis catus	AKAP7	VGNC	VGNC:59717

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