ONECUT2 - one cut homeobox 2 Gene

Homo sapiens

Also known as OC2; OC-2

Gene ID: 9480 | Gene type: protein coding

About ONECUT2

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:57,435,374-57,491,298 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 2 paralogues. Biased expression in gall bladder (RPKM 4.8), duodenum (RPKM 3.7) and 2 other tissues.

Summary

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

ONECUT2 Products(1)

mRNA	Protein	Name
NM_004852.3	NP_004843.2	one cut domain family member 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11478782	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11478782	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11478782	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ONECUT2 Protein Structure

CUT

Homeobox

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

one cut domain family member 2

HNF-6-beta

Related Diseases

Diseases

Alias

Ureter, Cancer Of

Ureter Carcinoma	Ureter Cancer
Ureteral Neoplasms	Malignant Neoplasm Of Ureter
Malignant Tumour Of Ureter	Malignant Ureteral Tumor
Ureteral Carcinoma	Ureteral Neoplasm

Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16	OI16
Oi, Type Xvi	Osteogenesis Imperfecta Type Xvi
Chromosome 11p11.2 Deletion Syndrome 91.3-Kb	Osteogenesis Imperfecta 16
Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Osteogenesis Imperfecta, Type Ii

Vrolik Type Of Osteogenesis Imperfecta	Osteogenesis Imperfecta Type 2
OI2	Oi, Type Ii
Osteogenesis Imperfecta Congenita	Oic
Osteogenesis Imperfecta Type Ii	Lethal Osteogenesis Imperfecta
Oi Type 2	Osteogenesis Imperfecta Congenita Perinatal Lethal Form
Osteogenesis Imperfecta Congenita, Perinatal Lethal Form	Perinatal Lethal Osteogenesis Imperfecta Congenita
Perinatally Lethal Oi	Osteogenesis Imperfecta 2
Oi-Ii	Oi-Iia
Oi Type Iia	Osteogenesis Imperfecta Type Iia
Osteogenesis Imperfecta Type Ii Autosomal Dominant	Oi Type Ii
Osteogenesis Imperfecta, Dominant Perinatal Lethal

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122611A	CSRM617 hydrochloride		99.97%	Unkown
HY-122611	CSRM617		/	Unkown
HY-RS09786	ONECUT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ONECUT2	VGNC	VGNC:53747
Mus musculus	ONECUT2	MGD	MGI:1891408
Macaca mulatta	ONECUT2	VGNC	VGNC:75585
Felis catus	ONECUT2	VGNC	VGNC:68627
Rattus norvegicus	ONECUT2	RGD	RGD:1564677
Bos taurus	ONECUT2	VGNC	VGNC:56369

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