CHST10 - carbohydrate sulfotransferase 10 Gene

Homo sapiens

Also known as HNK1ST; HNK-1ST

Gene ID: 9486 | Gene type: protein coding

About CHST10

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:100,391,860-100,417,668 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 6 paralogues. Broad expression in brain (RPKM 10.4), endometrium (RPKM 4.2) and 21 other tissues.

Summary

This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]

CHST10 Products(1)

mRNA	Protein	Name
NM_004854.5	NP_004845.1	carbohydrate sulfotransferase 10 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	23269668	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen metabolic process	IDA IDA: Inferred from direct assay	23269668	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	23269668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST10 Protein Structure

Sulfotransfer_2

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

carbohydrate sulfotransferase 10

HNK-1 sulfotransferase

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 33

RP33	Retinitis Pigmentosa, Type 33

Walker-Warburg Syndrome

Hard Syndrome	Walker-Warburg Congenital Muscular Dystrophy
Cerebroocular Dysplasia-Muscular Dystrophy Syndrome	Cod-Md Syndrome
Chemke Syndrome	Hydrocephalus, Agyria And Retinal Dysplasia
Cerebroocular Dysgenesis	Cerebroocular Dysplasia Muscular Dystrophy Syndrome
Hard +/- E Syndrome	Pagon Syndrome
Warburg Syndrome	Hydrocephalus, Agyria, And Retinal Dysplasia
Mddga	Muscular Dystrophy-Dystroglycanopathy , Type A
Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A	Hydrocephalus-Agyria-Retinal Dysplasia Syndrome
Wws	Dystrophy, Muscular, Dystroglycanopathy, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02682	CHST10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHST10	MGD	MGI:2138283
Canis familiaris	CHST10	VGNC	VGNC:39250
Felis catus	CHST10	VGNC	VGNC:60888
Bos taurus	CHST10	VGNC	VGNC:27338
Rattus norvegicus	CHST10	RGD	RGD:621216
Macaca mulatta	CHST10	VGNC	VGNC:71052

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