PGS1 - phosphatidylglycerophosphate synthase 1 Gene

Homo sapiens

Gene ID: 9489 | Gene type: protein coding

About PGS1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,378,649-78,424,659 (from NCBI)

This gene has 15 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in bone marrow (RPKM 9.6), appendix (RPKM 8.4) and 25 other tissues.

Summary

Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity and calcium ion binding activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

PGS1 Products(1)

mRNA	Protein	Name
NM_024419.5	NP_077733.3	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	38322995	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGS1 Protein Structure

PLDc_2

0
100
200
300
400
500
556 a.a.

Protein Preferred Names

Protein Names

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

PGP synthase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10401	PGS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PGS1	VGNC	VGNC:64127
Rattus norvegicus	PGS1	RGD	RGD:1305052
Bos taurus	PGS1	VGNC	VGNC:32803
Macaca mulatta	PGS1	VGNC	VGNC:75890
Canis familiaris	PGS1	VGNC	VGNC:44472
Mus musculus	PGS1	MGD	MGI:1921701

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