2. Gene
  3. GAL3ST1 - galactose-3-O-sulfotransferase 1 Gene

GAL3ST1 - galactose-3-O-sulfotransferase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CST

Gene ID: 9514 | Gene type: protein coding

About GAL3ST1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,554,635-30,574,665 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 3 paralogues. Biased expression in kidney (RPKM 2.0), duodenum (RPKM 1.8) and 9 other tissues.

Summary

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, Hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded Enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced Insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GAL3ST1 Products(15)

mRNA Protein Name
NM_001318103.2 NP_001305032.1 galactosylceramide sulfotransferase isoform 1
NM_001318104.2 NP_001305033.1 galactosylceramide sulfotransferase isoform 1
NM_001318105.2 NP_001305034.1 galactosylceramide sulfotransferase isoform 1
NM_001318106.2 NP_001305035.1 galactosylceramide sulfotransferase isoform 1
NM_001318107.2 NP_001305036.1 galactosylceramide sulfotransferase isoform 2
NM_001318108.2 NP_001305037.1 galactosylceramide sulfotransferase isoform 1
NM_001318109.1 NP_001305038.1 galactosylceramide sulfotransferase isoform 3
NM_001318110.2 NP_001305039.1 galactosylceramide sulfotransferase isoform 1
NM_001318111.2 NP_001305040.1 galactosylceramide sulfotransferase isoform 1
NM_001318112.2 NP_001305041.1 galactosylceramide sulfotransferase isoform 1
NM_001318113.2 NP_001305042.1 galactosylceramide sulfotransferase isoform 1
NM_001318114.2 NP_001305043.1 galactosylceramide sulfotransferase isoform 2
NM_001318115.2 NP_001305044.1 galactosylceramide sulfotransferase isoform 1
NM_001318116.2 NP_001305045.1 galactosylceramide sulfotransferase isoform 1
NM_004861.3 NP_004852.1 galactosylceramide sulfotransferase isoform 1

GAL3ST1 Protein Structure

Gal-3-0_sulfotr

Gal-3-0_sulfotr: Galactose-3-O-sulfotransferase (4 - 407)

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  • 423 a.a.
Protein Preferred Names Protein Names

galactosylceramide sulfotransferase

3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase

Related Diseases

Diseases Alias
Metachromatic Leukodystrophy

Arylsulfatase A Deficiency

MLD

Arsa Deficiency

Sulfatide Lipidosis

Metachromatic Leukoencephalopathy

Cerebral Sclerosis, Diffuse, Metachromatic Form

Cerebroside Sulfatase Deficiency

Leukodystrophy, Metachromatic

Pseudoarylsulfatase A Deficiency

Leukodystrophy Metachromatic

Sulfatidosis

Metachromatic Leukodystrophy, Late Infantile

Metachromatic Leukodystrophy Variant

Deficiency Of Cerebroside-Sulfatase

Scholz Cerebral Sclerosis

Sulfatide Lipoidosis

Cerebral Sclerosis Diffuse Metachromatic Form

Arylsulfatase A Deficiency Disease

Cerebroside Sulphatase Deficiency Disease

Greenfield Disease

Metachromatic Leukodystrophy, Adult

Metachromatic Leukodystrophy, Juvenile

Leukodystrophy Metachromatic Adult

Leukodystrophy Metachromatic Juvenile

Leukodystrophy Metachromatic Late Infantile

Metachromatic Leukodystrophy, Adult Type

Metachromatic Leukodystrophy, Juvenile Type

Metachromatic Leukodystrophy, Infant

Greenfield'S Disease
Developmental And Epileptic Encephalopathy 84

DEE84

Jamuar Syndrome

Eiee84

Developmental And Epileptic Encephalopathy, 84

Epileptic Encephalopathy, Early Ifantile, 84

Early Infantile Epileptic Encephalopathy 84

Epileptic Encephalopathy, Early Infantile, 84

Encephalopathy, Epileptic, Early Infantile, Type 84
Leukodystrophy

Leukodystrophies
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05239 GAL3ST1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GAL3ST1 VGNC VGNC:107791
Mus musculus GAL3ST1 MGD MGI:1858277
Felis catus GAL3ST1 VGNC VGNC:80441
Canis familiaris GAL3ST1 VGNC VGNC:41076
Rattus norvegicus GAL3ST1 RGD RGD:1583379
Bos taurus GAL3ST1 VGNC VGNC:29213