KIF20B - kinesin family member 20B Gene

Homo sapiens

Also known as CT90; MPP1; KRMP1; MPP-1; MPHOSPH1

Gene ID: 9585 | Gene type: protein coding

About KIF20B

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,701,590-89,774,934 (from NCBI)

This gene has 4 transcripts (splice variants) and 269 orthologues. Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues.

Summary

Enables several functions, including WW domain binding activity; plus-end-directed microtubule motor activity; and protein homodimerization activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

KIF20B Products(3)

mRNA	Protein	Name
NM_001284259.2	NP_001271188.1	kinesin-like protein KIF20B isoform 1
NM_001382506.1	NP_001369435.1	kinesin-like protein KIF20B isoform 3
NM_016195.4	NP_057279.2	kinesin-like protein KIF20B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	11470801	GOA
enables WW domain binding	IPI IPI: Inferred from physical interaction	11470801	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	12740395	GOA
enables plus-end-directed microtubule motor activity	IDA IDA: Inferred from direct assay	12740395	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17409436	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11470801	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12740395	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	12740395	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	11470801	GOA
located in contractile ring	IDA IDA: Inferred from direct assay	17409436	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8885239	GOA
located in midbody	IDA IDA: Inferred from direct assay	12740395	GOA
located in mitotic spindle midzone	IDA IDA: Inferred from direct assay	12740395	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	11470801	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	11470801	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	11470801	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12740395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF20B Protein Structure

Kinesin

0
300
600
900
1200
1500
1820 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF20B

M-phase phosphoprotein 1

Related Diseases

Diseases

Alias

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07273	KIF20B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF20B	MGD	MGI:2444576
Canis familiaris	KIF20B	VGNC	VGNC:42395
Rattus norvegicus	KIF20B	RGD	RGD:1308497
Bos taurus	KIF20B	VGNC	VGNC:107297
Macaca mulatta	KIF20B	VGNC	VGNC:74035

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