CREB5 - cAMP responsive element binding protein 5 Gene

Homo sapiens

Also known as CREB-5; CREBPA; CRE-BPA

Gene ID: 9586 | Gene type: protein coding

About CREB5

Cytogenetic location: 7p15.1-p14.3 Genomic coordinates (GRCh38): 7:28,299,321-28,825,894 (from NCBI)

This gene has 15 transcripts (splice variants), 245 orthologues and 2 paralogues. Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues.

Summary

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

CREB5 Products(4)

mRNA	Protein	Name
NM_001011666.3	NP_001011666.1	cyclic AMP-responsive element-binding protein 5 isoform delta
NM_004904.4	NP_004895.2	cyclic AMP-responsive element-binding protein 5 isoform beta
NM_182898.4	NP_878901.2	cyclic AMP-responsive element-binding protein 5 isoform alpha
NM_182899.5	NP_878902.2	cyclic AMP-responsive element-binding protein 5 isoform gamma

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8378084	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8440710	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8378084	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB5 Protein Structure

bZIP_1

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 5

cAMP response element-binding protein CRE-BPa

Related Diseases

Diseases

Alias

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Achalasia

Cardiospasm	Achalasia Of Cardia
Esophageal Achalasia	Hypertensive Lower Esophageal Sphincter
Idiopathic Achalasia	Achalasia Cardia
Idiopathic Achalasia Of Esophagus	Primary Achalasia
Achalasia Of Esophagus	Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter
Aperistalsis Of The Oesophagus	Achalasia Of Oesophagus
Oesophageal Achalasia	Achalasia Nos
Cardia Spasm	Cardia Achalasia
Oesophageal Cardiospasm	Oesophagus Achalasia
Reflex Cardiospasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03154	CREB5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CREB5	VGNC	VGNC:39600
Felis catus	CREB5	VGNC	VGNC:61170
Mus musculus	CREB5	MGD	MGI:2443973
Rattus norvegicus	CREB5	RGD	RGD:1566107
Macaca mulatta	CREB5	VGNC	VGNC:81295
Bos taurus	CREB5	VGNC	VGNC:106699

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