LPIN2 - lipin 2 Gene

Homo sapiens

Gene ID: 9663 | Gene type: protein coding

About LPIN2

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:2,916,994-3,013,144 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 28.7), duodenum (RPKM 22.4) and 25 other tissues.

Summary

Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and Insulin resistance. [provided by RefSeq, Jul 2008]

LPIN2 Products(3)

mRNA	Protein	Name
NM_001375808.2	NP_001362737.1	phosphatidate phosphatase LPIN2
NM_001375809.1	NP_001362738.1	phosphatidate phosphatase LPIN2
NM_014646.2	NP_055461.1	phosphatidate phosphatase LPIN2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidate phosphatase activity	EXP EXP: Inferred from Experiment	18694939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPIN2 Protein Structure

Lipin_N

LNS2

0
200
400
600
800
896 a.a.

Protein Preferred Names

Protein Names

phosphatidate phosphatase LPIN2

Related Diseases

Diseases

Alias

Majeed Syndrome

MJDS	Chronic Recurrent Multifocal Osteomyelitis, Congenital Dyserythropoietic Anemia, And Neutrophilic Dermatosis
Cda And Crmo	Chronic Recurrent Multifocal Osteomyelitis, Congenital
Congenital Dyserythropoietic Anemia And Chronic Recurrent Multifocal Osteomyelitis	Dyserythropoietic Anemia, And Neutrophilic Dermatosis
Chronic Recurrent Multifocal Osteomyelitis-Congenital Dyserythropoietic Anemia-Neutrophilic Dermatosis Syndrome	Chronic Recurrent Multifocal Osteomyelitis With Congenital Dyserythropoietic Anemia And Neutrophilic Dermatosis

Chronic Recurrent Multifocal Osteomyelitis

Chronic Multifocal Osteomyelitis	CRMO
Cmo	Cno/Crmo
Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis	Osteomyelitis, Chronic Multifocal
Multifocal Osteomyelitis, Chronic	Chronic Osteomyelitis
Chronic Multifocal Osteomyelitis, Unspecified Site	Crmo - [Chronic Multifocal Osteomyelitis]
Chronic Osteomyelitis With Draining Sinus, Unspecified Site	Bone Fistula With Chronic Osteomyelitis

Osteomyelitis

Autoinflammatory Syndrome

Hypochromic Microcytic Anemia

Anemia, Hypochromic Microcytic

Microcytic Hypochromic Anemia

Sapho Syndrome

Acquired Hyperostosis Syndrome	Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome
Synovitis Acne Pustulosis Hyperostosis Osteitis	Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis
Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome	Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome
Pustulo-Psoriatic Hyperostotic Spondylarthritis	Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome

Congenital Dyserythropoietic Anemia

Congenital Dyshaematopoietic Anaemia	Dyserythropoietic Anemia, Congenital
Cda	Anemia, Dyserythropoietic, Congenital
Anemia Dyserythropoietic Congenital	Cda - [Congenital Dyserythropoietic Anaemia]
Dyserythropoietic Dyshaematopoietic Congenital Anaemia	Dyshaematopoietic Anaemia
Dyserythropoietic Anaemia

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

Papa Syndrome	Fra
Familial Recurrent Arthritis	Pyogenic Arthritis, Pyoderma Gangrenosum And Acne
PAPAS	Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne	Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne

Miliaria Pustulosa

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome	Acute Febrile Neutrophilic Dermatosis
Ss	AFND
Pyrin-Associated Autoinflammatory Disease	PAAND
Gomm-Button Disease	Sweet'S Syndrome
Gomm Button Disease	Sweets Syndrome
Acromelic Frontonasal Dysostosis	Sweet Disease

Periostitis

Pustulosis Of Palm And Sole

Psoriasis	Acropustulosis
Palmoplantar Pustulosis	Pustular Psoriasis Of The Palms And/Or Soles
Pustulosis Of Palms And Soles	Acrodermatitis Continua Of Hallopeau
Generalized Pustular Psoriasis

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Pyoderma Gangrenosum

Phagedenic Pyoderma

Phagedena Geometric

Mevalonic Aciduria

Mevalonate Kinase Deficiency	Mevalonicaciduria
Hyperimmunoglobulin D With Periodic Fever	MEVA
Complete Mevalonate Kinase Deficiency	Mva
Hyperimmunoglobulinemia D	Hyper Igd Syndrome
Periodic Fever, Dutch Type	Mkd
Aciduria, Mevalonic	Deficiency Of Mevalonate Kinase

Sebaceous Gland Disease

Sebaceous Gland Anomaly

Sebaceous Gland Diseases

Pyoderma

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07770	LPIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LPIN2	VGNC	VGNC:63269
Mus musculus	LPIN2	MGD	MGI:1891341
Bos taurus	LPIN2	VGNC	VGNC:30967
Rattus norvegicus	LPIN2	RGD	RGD:1304588
Macaca mulatta	LPIN2	VGNC	VGNC:74288
Canis familiaris	LPIN2	VGNC	VGNC:42752

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