ST18 - ST18 C2H2C-type zinc finger transcription factor Gene

Homo sapiens

Also known as NZF3; NZF-3; ZNF387; ZC2H2C3; ZC2HC10

Gene ID: 9705 | Gene type: protein coding

About ST18

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,110,838-52,409,879 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues and 5 paralogues. Biased expression in brain (RPKM 3.7), stomach (RPKM 0.7) and 3 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytokine-mediated signaling pathway; negative regulation of cell population proliferation; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

ST18 Products(60)

mRNA	Protein	Name
NM_001352826.2	NP_001339755.1	suppression of tumorigenicity 18 protein isoform a
NM_001352827.2	NP_001339756.1	suppression of tumorigenicity 18 protein isoform a
NM_001352828.2	NP_001339757.1	suppression of tumorigenicity 18 protein isoform a
NM_001352829.2	NP_001339758.1	suppression of tumorigenicity 18 protein isoform a
NM_001352830.2	NP_001339759.1	suppression of tumorigenicity 18 protein isoform a
NM_001352831.2	NP_001339760.1	suppression of tumorigenicity 18 protein isoform a
NM_001352832.2	NP_001339761.1	suppression of tumorigenicity 18 protein isoform a
NM_001352833.2	NP_001339762.1	suppression of tumorigenicity 18 protein isoform a
NM_001352834.2	NP_001339763.1	suppression of tumorigenicity 18 protein isoform a
NM_001352835.2	NP_001339764.1	suppression of tumorigenicity 18 protein isoform a
NM_001352836.2	NP_001339765.1	suppression of tumorigenicity 18 protein isoform a
NM_001352837.2	NP_001339766.1	suppression of tumorigenicity 18 protein isoform a
NM_001352838.2	NP_001339767.1	suppression of tumorigenicity 18 protein isoform a
NM_001352839.2	NP_001339768.1	suppression of tumorigenicity 18 protein isoform a
NM_001352840.2	NP_001339769.1	suppression of tumorigenicity 18 protein isoform a
NM_001352841.2	NP_001339770.1	suppression of tumorigenicity 18 protein isoform a
NM_001352842.2	NP_001339771.1	suppression of tumorigenicity 18 protein isoform a
NM_001352843.2	NP_001339772.1	suppression of tumorigenicity 18 protein isoform a
NM_001352844.2	NP_001339773.1	suppression of tumorigenicity 18 protein isoform a
NM_001352845.2	NP_001339774.1	suppression of tumorigenicity 18 protein isoform a
NM_001352846.2	NP_001339775.1	suppression of tumorigenicity 18 protein isoform a
NM_001352847.2	NP_001339776.1	suppression of tumorigenicity 18 protein isoform a
NM_001352848.2	NP_001339777.1	suppression of tumorigenicity 18 protein isoform a
NM_001352849.2	NP_001339778.1	suppression of tumorigenicity 18 protein isoform a
NM_001352850.2	NP_001339779.1	suppression of tumorigenicity 18 protein isoform a
NM_001352851.2	NP_001339780.1	suppression of tumorigenicity 18 protein isoform a
NM_001352852.2	NP_001339781.1	suppression of tumorigenicity 18 protein isoform a
NM_001352853.2	NP_001339782.1	suppression of tumorigenicity 18 protein isoform a
NM_001352854.2	NP_001339783.1	suppression of tumorigenicity 18 protein isoform a
NM_001352855.2	NP_001339784.1	suppression of tumorigenicity 18 protein isoform a
NM_001352856.2	NP_001339785.1	suppression of tumorigenicity 18 protein isoform a
NM_001352857.2	NP_001339786.1	suppression of tumorigenicity 18 protein isoform a
NM_001352858.2	NP_001339787.1	suppression of tumorigenicity 18 protein isoform c
NM_001352859.2	NP_001339788.1	suppression of tumorigenicity 18 protein isoform c
NM_001352860.2	NP_001339789.1	suppression of tumorigenicity 18 protein isoform c
NM_001352861.2	NP_001339790.1	suppression of tumorigenicity 18 protein isoform b
NM_001352862.2	NP_001339791.1	suppression of tumorigenicity 18 protein isoform b
NM_001352863.2	NP_001339792.1	suppression of tumorigenicity 18 protein isoform b
NM_001352864.2	NP_001339793.1	suppression of tumorigenicity 18 protein isoform b
NM_001352865.2	NP_001339794.1	suppression of tumorigenicity 18 protein isoform b
NM_001352866.2	NP_001339795.1	suppression of tumorigenicity 18 protein isoform b
NM_001352867.2	NP_001339796.1	suppression of tumorigenicity 18 protein isoform b
NM_001352868.2	NP_001339797.1	suppression of tumorigenicity 18 protein isoform b
NM_001352869.2	NP_001339798.1	suppression of tumorigenicity 18 protein isoform b
NM_001352870.2	NP_001339799.1	suppression of tumorigenicity 18 protein isoform d
NM_001352871.2	NP_001339800.1	suppression of tumorigenicity 18 protein isoform d
NM_001352872.2	NP_001339801.1	suppression of tumorigenicity 18 protein isoform d
NM_001352873.2	NP_001339802.1	suppression of tumorigenicity 18 protein isoform d
NM_001352874.2	NP_001339803.1	suppression of tumorigenicity 18 protein isoform d
NM_001352875.2	NP_001339804.1	suppression of tumorigenicity 18 protein isoform d
NM_001352876.2	NP_001339805.1	suppression of tumorigenicity 18 protein isoform f
NM_001352877.2	NP_001339806.1	suppression of tumorigenicity 18 protein isoform e
NM_001352878.2	NP_001339807.1	suppression of tumorigenicity 18 protein isoform e
NM_001352879.1	NP_001339808.1	suppression of tumorigenicity 18 protein isoform g
NM_001352880.1	NP_001339809.1	suppression of tumorigenicity 18 protein isoform g
NM_001352881.1	NP_001339810.1	suppression of tumorigenicity 18 protein isoform g
NM_001352882.1	NP_001339811.1	suppression of tumorigenicity 18 protein isoform g
NM_001352883.2	NP_001339812.1	suppression of tumorigenicity 18 protein isoform h
NM_001352884.2	NP_001339813.1	suppression of tumorigenicity 18 protein isoform h
NM_014682.3	NP_055497.1	suppression of tumorigenicity 18 protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18676404	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18676404	GOA
involved in interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18676404	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15489893	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	18676404	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18676404	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18676404	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15489893	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	18676404	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST18 Protein Structure

zf-C2HC

MYT1

zf-C2HC

0
200
400
600
800
1047 a.a.

Protein Preferred Names

Protein Names

suppression of tumorigenicity 18 protein

ST18, C2H2C-type zinc finger

Related Diseases

Diseases

Alias

Pemphigus

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13845	ST18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ST18	RGD	RGD:708566
Felis catus	ST18	VGNC	VGNC:65718
Canis familiaris	ST18	VGNC	VGNC:46849
Bos taurus	ST18	VGNC	VGNC:35330
Macaca mulatta	ST18	VGNC	VGNC:77959
Mus musculus	ST18	MGD	MGI:2446700
Others	ST18	NCBI

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