2. Gene
  3. ULK2 - unc-51 like autophagy activating kinase 2 Gene

ULK2 - unc-51 like autophagy activating kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATG1B; Unc51.2

Gene ID: 9706 | Gene type: protein coding

About ULK2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,770,830-19,867,936 (from NCBI)

This gene has 11 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.5), brain (RPKM 7.4) and 21 other tissues.

Summary

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

ULK2 Products(5)

mRNA Protein Name
NM_001142610.2 NP_001136082.1 serine/threonine-protein kinase ULK2
XM_047437147.1 XP_047293103.1 serine/threonine-protein kinase ULK2 isoform X2
NM_014683.4 NP_055498.3 serine/threonine-protein kinase ULK2
XM_047437148.1 XP_047293104.1 serine/threonine-protein kinase ULK2 isoform X3
XM_017025425.3 XP_016880914.1 serine/threonine-protein kinase ULK2 isoform X1

ULK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (10 - 271)

DUF3543

DUF3543: Domain of unknown function (DUF3543) (816 - 1032)

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  • 1036 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK2

Related Diseases

Diseases Alias
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16966 SBI-0206965 Inhibitor 99.39% Unkown
HY-13018 MRT67307 Inhibitor 99.34% Unkown
HY-114490 ULK-101 Inhibitor 99.96% Unkown
HY-160699 DCC-3116 Inhibitor 99.25% Unkown
HY-137742 SBP-7455 Inhibitor 98.24% Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-162100 MR-2088 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ULK2 VGNC VGNC:78926
Felis catus ULK2 VGNC VGNC:66815
Mus musculus ULK2 MGD MGI:1352758
Rattus norvegicus ULK2 RGD RGD:1310181
Bos taurus ULK2 VGNC VGNC:36659
Canis familiaris ULK2 VGNC VGNC:48129