2. Gene
  3. USP34 - ubiquitin specific peptidase 34 Gene

USP34 - ubiquitin specific peptidase 34 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9736 | Gene type: protein coding

About USP34

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,187,463-61,471,087 (from NCBI)

This gene has 22 transcripts (splice variants), 186 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 17.6), lymph node (RPKM 17.0) and 25 other tissues.

Summary

Enables cysteine-type endopeptidase activity and thiol-dependent Deubiquitinase. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP34 Products(1)

mRNA Protein Name
NM_014709.4 NP_055524.3 ubiquitin carboxyl-terminal hydrolase 34
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21383061 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21383061 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
21383061 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
21383061 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP34 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (1894 - 2236)

  • 0
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  • 3000
  • 3546 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 34

deubiquitinating enzyme 34

Related Diseases

Diseases Alias
Chromosome 2p16.1-P15 Deletion Syndrome

2p15p16.1 Microdeletion Syndrome

2p15-P16.1 Microdeletion Syndrome

Del(2)(P15p16.1)

Monosomy 2p15p16.1

Monosomy 2p15-P16.1
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Meningocele

Isolated Spina Bifida

Spina Bifida

Cleft Spine

Open Spine

Rachischisis

Spinal Dysraphism

Spinal Meningocele

Congenital Meningocele
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15545 USP34 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP34 RGD RGD:1565181
Felis catus USP34 VGNC VGNC:66880
Mus musculus USP34 MGD MGI:109473
Macaca mulatta USP34 VGNC VGNC:79223
Canis familiaris USP34 VGNC VGNC:48190
Bos taurus USP34 VGNC VGNC:36724