2. Gene
  3. PCLAF - PCNA clamp associated factor Gene

PCLAF - PCNA clamp associated factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)

Gene ID: 9768 | Gene type: protein coding

About PCLAF

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,364,304-64,387,687 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Biased expression in bone marrow (RPKM 26.4), lymph node (RPKM 13.8) and 11 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PCLAF Products(2)

mRNA Protein Name
NM_001029989.3 NP_001025160.1 PCNA-associated factor isoform 2
NM_014736.6 NP_055551.1 PCNA-associated factor isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23000965 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
25762514 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
25762514 GOA
enables molecular adaptor activity IPI
IPI: Inferred from physical interaction
25762514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21628590 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
21628590 GOA
involved in DNA replication IDA
IDA: Inferred from direct assay
23000965 GOA
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
21673012 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
21628590 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
23000965 GOA
involved in translesion synthesis IMP
IMP: Inferred from mutant phenotype
23000965 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
21628590 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21673012 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PCNA-associated factor

HCV NS5A-transactivated protein 9

PCLAF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PCLAF Q15004 PCNA Homo sapiens P12004
Y2H Array
32296183
Intra
PCLAF Q15004 PCNA Homo sapiens P12004
Y2H Prey Pooling
32296183
Intra
PCLAF Q15004 TERF1 Homo sapiens P54274-2
Y2H Prey Pooling
32296183
Intra
PCLAF Q15004 TERF1 Homo sapiens P54274-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PCLAF Proteins

Cat. No. Product Name Accession Purity
HY-P75900 KIAA0101 Protein, Human (His) Q15004-1 (M1-E111) ≥95%

Related Diseases

Diseases Alias
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia
Anomalous Left Coronary Artery From The Pulmonary Artery

Bland White Garland Syndrome

Alcapa

Bland-White-Garland Syndrome

White-Garland Syndrome
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149428 AD4 98.01% Unkown
HY-162393 XL44 Activator 98.00% Unkown
HY-RS10154 PCLAF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PCLAF MGD MGI:1915276
Rattus norvegicus PCLAF RGD RGD:1303041
Others PCLAF NCBI