2. Apoptosis
  3. Apoptosis
  4. XL44

XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins.

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XL44 Chemical Structure

XL44 Chemical Structure

CAS No. : 2637949-91-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

XL44 Related Antibodies

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Description

XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins[1].

In Vitro

XL44 (20 μM, 4-24 h, lysates from RPMI 8226 cells) induces apoptosis in an hRpn13-dependent manner and reduces hRpn13Pru levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XL44 Related Antibodies

Western Blot Analysis[1].

Cell Line: Lysates from RPMI 8226 cells.
Concentration: 20 μM.
Incubation Time: 4-24 h.
Result: Caused a reduction in hRpn13Pru levels in RPMI 8226 WT cells.
Molecular Weight

388.39

Formula

C23H17FN2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(OC)C=C1)NC2=CC=CC(/C=C3C(NC4=C\3C=C(F)C=C4)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (51.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5747 mL 12.8737 mL 25.7473 mL
5 mM 0.5149 mL 2.5747 mL 5.1495 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5747 mL 12.8737 mL 25.7473 mL 64.3683 mL
5 mM 0.5149 mL 2.5747 mL 5.1495 mL 12.8737 mL
10 mM 0.2575 mL 1.2874 mL 2.5747 mL 6.4368 mL
15 mM 0.1716 mL 0.8582 mL 1.7165 mL 4.2912 mL
20 mM 0.1287 mL 0.6437 mL 1.2874 mL 3.2184 mL
25 mM 0.1030 mL 0.5149 mL 1.0299 mL 2.5747 mL
30 mM 0.0858 mL 0.4291 mL 0.8582 mL 2.1456 mL
40 mM 0.0644 mL 0.3218 mL 0.6437 mL 1.6092 mL
50 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.2874 mL
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XL44 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XL442637949-91-6XL 44XL-44ApoptosishRpn13PruKENapoptosisInhibitorinhibitorinhibit

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