PHYHIP - phytanoyl-CoA 2-hydroxylase interacting protein Gene

Homo sapiens

Also known as PAHX-AP; PAHXAP1; DYRK1AP3

Gene ID: 9796 | Gene type: protein coding

About PHYHIP

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,219,703-22,232,099 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 1 paralogue. Biased expression in brain (RPKM 50.0), skin (RPKM 16.9) and 4 other tissues.

Summary

Enables protein tyrosine kinase binding activity. Involved in protein localization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PHYHIP Products(4)

mRNA	Protein	Name
NM_001099335.2	NP_001092805.1	phytanoyl-CoA hydroxylase-interacting protein
NM_001363311.2	NP_001350240.1	phytanoyl-CoA hydroxylase-interacting protein
NM_001363312.2	NP_001350241.1	phytanoyl-CoA hydroxylase-interacting protein
NM_014759.5	NP_055574.3	phytanoyl-CoA hydroxylase-interacting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	15694837	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization	IDA IDA: Inferred from direct assay	15694837	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15694837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phytanoyl-CoA hydroxylase-interacting protein

DYRK1A interacting protein 3

Related Diseases

Diseases

Alias

Refsum Disease, Classic

Refsum Disease	Heredopathia Atactica Polyneuritiformis
Phytanic Acid Oxidase Deficiency	Hmsn Iv
Refsum Disease, Adult, 1	Refsum'S Disease
Phytanic Acid Storage Disease	Hereditary Motor And Sensory Neuropathy Iv
Hmsn4	Hmsn Type Iv
Hmsn 4	Adult Refsum Disease
Classic Refsum Disease	Hereditary Motor And Sensory Neuropathy Type Iv
Refsum Syndrome	Hsmn Iv
Disorder Of Cornification 11	Doc 11
Hereditary Sensory And Motor Neuropathy Type 4	Hypertrophic Neuropathy Of Refsum
Ard	Crd
Hereditary Motor And Sensory Neuropathy Type 4	Phytanic-Coa Hydroxylase Deficiency
RD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10459	PHYHIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PHYHIP	VGNC	VGNC:75812
Canis familiaris	PHYHIP	VGNC	VGNC:44512
Felis catus	PHYHIP	VGNC	VGNC:64156
Mus musculus	PHYHIP	MGD	MGI:1860417
Bos taurus	PHYHIP	VGNC	VGNC:32850
Rattus norvegicus	PHYHIP	RGD	RGD:1305790

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