2. Gene
  3. FARP2 - FERM, ARH/RhoGEF and pleckstrin domain protein 2 Gene

FARP2 - FERM, ARH/RhoGEF and pleckstrin domain protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FIR; FRG; PLEKHC3

Gene ID: 9855 | Gene type: protein coding

About FARP2

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,356,285-241,494,841 (from NCBI)

This gene has 23 transcripts (splice variants), 215 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 7.0), skin (RPKM 5.6) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within Rac protein signal transduction and neuron remodeling. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FARP2 Products(3)

mRNA Protein Name
NM_001282983.2 NP_001269912.1 FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b
NM_001282984.2 NP_001269913.1 FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform c
NM_014808.4 NP_055623.1 FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12351724 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Rac protein signal transduction IDA
IDA: Inferred from direct assay
12351724 GOA
acts upstream of or within neuron remodeling IDA
IDA: Inferred from direct assay
12351724 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12351724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARP2 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (48 - 125)

FERM_M

FERM_M: FERM central domain (127 - 234)

FERM_C

FERM_C: FERM C-terminal PH-like domain (238 - 327)

FA

FA: FERM adjacent (FA) (333 - 377)

RhoGEF

RhoGEF: RhoGEF domain (539 - 722)

PH

PH: PH domain (757 - 851)

PH

PH: PH domain (932 - 1025)

  • 0
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  • 1000
  • 1054 a.a.
Protein Preferred Names Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 2

FERM domain including RhoGEF

Related Diseases

Diseases Alias
Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome

2q37 Microdeletion Syndrome

Brachydactyly-Intellectual Disability Syndrome

Deletion 2q37

2q37 Deletion Syndrome

Brachydactyly-Mental Retardation Syndrome

Bdmr

Albright Hereditary Osteodystrophy Type 3

Del(2)(Q37)

Monosomy 2q37qter

Albright'S Hereditary Osteodystrophy-Like Syndrome

Monosomy 2q37

Chromosome Deletion Syndrome 2q37
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome
Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6

Parkinson Disease 6

PARK6

Parkinson Disease 6, Early Onset

Parkinson'S Disease 6

Parkinson Disease 6, Early-Onset

Autosomal Recessive Early-Onset Parkinson'S Disease 6

Early-Onset Parkinson Disease 6

Autosomal Recessive Early-Onset Parkinson Disease Type 6

Parkinson Disease 6 Early-Onset

Parkinson Disease 6 Late-Onset Susceptibility To

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

Parkinsonism Young Adult Onset

Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Pathologic Nystagmus

Nystagmus
Congenital Nystagmus

Nystagmus, Congenital

Nystagmus Congenital
Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

HPS1

Delta Storage Pool Disease

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Hermansky-Pudlak Syndrome, Type 1

Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04747 FARP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FARP2 VGNC VGNC:62150
Canis familiaris FARP2 VGNC VGNC:40731
Macaca mulatta FARP2 VGNC VGNC:72513
Rattus norvegicus FARP2 RGD RGD:1308003
Mus musculus FARP2 MGD MGI:2385126
Bos taurus FARP2 VGNC VGNC:55172