AREL1 - apoptosis resistant E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Also known as FIEL1; KIAA0317

Gene ID: 9870 | Gene type: protein coding

About AREL1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:74,661,256-74,713,080 (from NCBI)

This gene has 18 transcripts (splice variants), 205 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 15.1), thyroid (RPKM 12.5) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

AREL1 Products(2)

mRNA	Protein	Name
NM_001039479.2	NP_001034568.1	apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1
NM_001411046.1	NP_001397975.1	apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23479728	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	25752577	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23479728	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	23479728	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	25752577	GOA
involved in protein K33-linked ubiquitination	IDA IDA: Inferred from direct assay	25752577	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	31578312	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23479728	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	23479728	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AREL1 Protein Structure

Filamin

HECT

0
200
400
600
823 a.a.

Protein Preferred Names

Protein Names

apoptosis-resistant E3 ubiquitin protein ligase 1

apoptosis-resistant HECT-type E3 ubiquitin transferase 1

Related Diseases

Diseases

Alias

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7	Hereditary Nonpolyposis Colorectal Cancer Type 7
Hereditary Non-Polyposis Colorectal Cancer 7	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00893	AREL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AREL1	MGD	MGI:1915747
Canis familiaris	AREL1	VGNC	VGNC:38029
Felis catus	AREL1	VGNC	VGNC:59865
Rattus norvegicus	AREL1	RGD	RGD:1307597
Bos taurus	AREL1	VGNC	VGNC:26058

Name
Email *

	Sorry, but the email address you supplied was invalid.