LPGAT1 - lysophosphatidylglycerol acyltransferase 1 Gene

Homo sapiens

Also known as NET8; FAM34A; LPLAT7; FAM34A1

Gene ID: 9926 | Gene type: protein coding

About LPGAT1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,743,457-211,830,763 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 15.0), thyroid (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

LPGAT1 Products(6)

mRNA	Protein	Name
NM_001320808.2	NP_001307737.1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375841.1	NP_001362770.1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375842.1	NP_001362771.1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375844.1	NP_001362773.1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2
NM_001375845.1	NP_001362774.1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2
NM_014873.3	NP_055688.1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	36049524	GOA
enables lysophospholipid acyltransferase activity	IDA IDA: Inferred from direct assay	36049524	GOA
enables lysophospholipid acyltransferase activity	IMP IMP: Inferred from mutant phenotype	15485873	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	23749231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10942595	GOA
located in endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	15485873	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPGAT1 Protein Structure

Acyltransferase

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

acyl-CoA:lysophosphatidylglycerol acyltransferase 1

acyl-CoA:monoacylglycerol acyltransferase LPGAT1

Related Diseases

Diseases

Alias

Progressive Familial Heart Block, Type Ii

PFHB2	Pfhbii
Progressive Familial Heart Block Type Ii	Progressive Familial Heart Block Type 2
Heart Block Progressive Familial Type 2

Cardiomyopathy, Dilated, 1d

Dilated Cardiomyopathy 1d	CMD1D
Left Ventricular Noncompaction 6, Included	Lvnc6, Included
Left Ventricular Noncompaction 6	Cardiomyopathy, Dilated 1d

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07768	LPGAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LPGAT1	RGD	RGD:1585897
Mus musculus	LPGAT1	MGD	MGI:2446186
Macaca mulatta	LPGAT1	VGNC	VGNC:74387
Bos taurus	LPGAT1	VGNC	VGNC:30965
Felis catus	LPGAT1	VGNC	VGNC:107894
Canis familiaris	LPGAT1	VGNC	VGNC:42750

Name
Email *

	Sorry, but the email address you supplied was invalid.