KIF14 - kinesin family member 14 Gene

Homo sapiens

Also known as MKS12; MCPH20

Gene ID: 9928 | Gene type: protein coding

About KIF14

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,551,497-200,620,751 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 41 paralogues and is associated with 5 phenotypes. Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues.

Summary

This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

KIF14 Products(15)

mRNA	Protein	Name
XM_047436199.1	XP_047292155.1	kinesin-like protein KIF14 isoform X6
XM_047436184.1	XP_047292140.1	kinesin-like protein KIF14 isoform X2
XM_011510235.3	XP_011508537.1	kinesin-like protein KIF14 isoform X5
XM_011510233.3	XP_011508535.1	kinesin-like protein KIF14 isoform X2
XM_011510232.3	XP_011508534.1	kinesin-like protein KIF14 isoform X1
XM_047436195.1	XP_047292151.1	kinesin-like protein KIF14 isoform X4
XM_017003006.2	XP_016858495.1	kinesin-like protein KIF14 isoform X3
XM_017003007.2	XP_016858496.1	kinesin-like protein KIF14 isoform X7
XM_047436181.1	XP_047292137.1	kinesin-like protein KIF14 isoform X2
XM_011510231.3	XP_011508533.1	kinesin-like protein KIF14 isoform X1
XM_047436197.1	XP_047292153.1	kinesin-like protein KIF14 isoform X5
XM_047436190.1	XP_047292146.1	kinesin-like protein KIF14 isoform X2
XM_047436198.1	XP_047292154.1	kinesin-like protein KIF14 isoform X5
NM_001305792.1	NP_001292721.1	kinesin-like protein KIF14 isoform 2
NM_014875.3	NP_055690.1	kinesin-like protein KIF14 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	23209302	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16431929	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16431929	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24854087	GOA
involved in activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	24784001	GOA
acts upstream of or within establishment of protein localization	IDA IDA: Inferred from direct assay	23209302	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24784001	GOA
acts upstream of or within negative regulation of integrin activation	IMP IMP: Inferred from mutant phenotype	23209302	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	24784001	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24854087	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16431929	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24854087	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	24854087	GOA
involved in regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	24854087	GOA
acts upstream of or within regulation of Rap protein signal transduction	IMP IMP: Inferred from mutant phenotype	23209302	GOA
acts upstream of or within regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23209302	GOA
involved in regulation of cell growth	IMP IMP: Inferred from mutant phenotype	24854087	GOA
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	23209302	GOA
acts upstream of or within substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	23209302	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in microtubule	IDA IDA: Inferred from direct assay	23209302	GOA
located in midbody	IDA IDA: Inferred from direct assay	16431929	GOA
colocalizes with plasma membrane	IPI IPI: Inferred from physical interaction	24784001	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	16431929	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF14 Protein Structure

Kinesin

FHA

0
300
600
900
1200
1500
1648 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF14

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Leukocoria

Leucocoria

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Desmoplastic/Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity
Desmoplastic Medulloblastoma	Medulloblastoma, Somatic
Medulloblastoma, Desmoplastic	Brain Medulloblastoma
Cns Pnet	Infratentorial Primitive Neuroectodermal Tumor
Mben	Medulloblastoma Desmoplastic
Neuroectodermal Tumors, Primitive	Medulloblastomas
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Meckel Syndrome 12

Lethal Fetal Cerebrorenogenitourinary Agenesis/Hypoplasia Syndrome	MKS12
Meckel Syndrome, Type 12

Microcephaly 5, Primary, Autosomal Recessive

MCPH5	Primary Autosomal Recessive Microcephaly 5
Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern	Microcephaly, Primary Autosomal Recessive, 5

Lissencephaly 4

LIS4	Lissencephaly 4 With Microcephaly
Microlissencephaly	Lissencephaly, Type 4

Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome	GOSHS
Megacolon-Microcephaly Syndrome

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Bilateral Retinoblastoma

Microcephaly 20, Primary, Autosomal Recessive

MCPH20

Unilateral Retinoblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07261	KIF14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07262	Kif14 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07263	Kif14 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KIF14	VGNC	VGNC:30583
Canis familiaris	KIF14	VGNC	VGNC:42383
Felis catus	KIF14	VGNC	VGNC:63103
Mus musculus	KIF14	MGD	MGI:1098226
Rattus norvegicus	KIF14	RGD	RGD:1310650
Macaca mulatta	KIF14	VGNC	VGNC:99990

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