MAGEC1 - MAGE family member C1 Gene

Homo sapiens

Also known as CT7; CT7.1

Gene ID: 9947 | Gene type: protein coding

About MAGEC1

Cytogenetic location: Xq27.2 Genomic coordinates (GRCh38): X:141,903,894-141,909,374 (from NCBI)

This gene has 2 transcripts (splice variants), 464 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 5.4).

Summary

This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the Other MAGE proteins. [provided by RefSeq, Jul 2008]

MAGEC1 Products(1)

mRNA	Protein	Name
NM_005462.5	NP_005453.2	melanoma-associated antigen C1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17137291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEC1 Protein Structure

MAGE

0
200
400
600
800
1000
1142 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen C1

MAGE-C1 antigen

MAGEC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAGEC1	O60732	CTAG1A	Homo sapiens	P78358	Y2H	17137291
Intra	MAGEC1	O60732	CTAG1A	Homo sapiens	P78358	Anti Bait CoIP	17137291
Intra	MAGEC1	O60732	CTAG1A	Homo sapiens	P78358	IF	17137291

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Malignant Anus Melanoma

Anal Melanoma

Malignant Melanoma Of Anus

Uterine Adnexa Cancer

Spermatocytoma

Spermatocytic Seminoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07973	MAGEC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAGEC1	MGD	MGI:1921687

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