HS3ST3B1 - heparan sulfate-glucosamine 3-sulfotransferase 3B1 Gene

Homo sapiens

Also known as 3OST3B1; 3-OST-3B; h3-OST-3B

Gene ID: 9953 | Gene type: protein coding

About HS3ST3B1

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:14,301,081-14,349,404 (from NCBI)

This gene has 2 transcripts (splice variants), 471 orthologues and 10 paralogues. Broad expression in liver (RPKM 6.8), lymph node (RPKM 3.1) and 21 other tissues.

Summary

The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

HS3ST3B1 Products(1)

mRNA	Protein	Name
NM_006041.3	NP_006032.1	heparan sulfate glucosamine 3-O-sulfotransferase 3B1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IDA IDA: Inferred from direct assay	9988768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycosaminoglycan biosynthetic process	IDA IDA: Inferred from direct assay	9988768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heparan sulfate glucosamine 3-O-sulfotransferase 3B1

heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Dihydropyrimidinase Deficiency

Dihydropyrimidinuria	Dpys Deficiency
Dph Deficiency	DPYSD
Dihydrouracil Amidohydrolase Deficiency	Dihydropyrimidinuria Due To Dpys Deficiency

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06379	HS3ST3B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HS3ST3B1	MGD	MGI:1333853
Rattus norvegicus	HS3ST3B1	RGD	RGD:1307326

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