CDC34 - cell division cycle 34, ubiqiutin conjugating enzyme Gene

Homo sapiens

Also known as UBC3; UBCH3; UBE2R1; E2-CDC34

Gene ID: 997 | Gene type: protein coding

About CDC34

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:531,760-542,087 (from NCBI)

This gene has 7 transcripts (splice variants), 126 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ubiquitin-conjugating Enzyme family. Ubiquitin-conjugating Enzyme catalyzes the covalent attachment of ubiquitin to Other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

CDC34 Products(1)

mRNA	Protein	Name
NM_004359.2	NP_004350.1	ubiquitin-conjugating enzyme E2 R1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10373550	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	20061386	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	10373550	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interferon-beta	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10373550	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	20347421	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	10373550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC34 Protein Structure

UQ_con

0
100
200
236 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 R1

(E3-independent) E2 ubiquitin-conjugating enzyme R1

CDC34 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC34	P49427	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CDC34	P49427	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CDC34	P49427	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CDC34	P49427	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	CDC34	P49427	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	CDC34	P49427	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
Intra	CDC34	P49427	CUL1	Homo sapiens	Q13616	FRET	19945379
Intra	CDC34	P49427	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	CDC34	P49427	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	CDC34	P49427	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	CDC34	P49427	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDC34 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79448	UBE2R1/CDC34 Protein, Human (Sf9, His, Strep)	P49427 (A2-S236)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15301	CC0651	Inhibitor	99.03%	Unkown
HY-RS02296	CDC34 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC34	VGNC	VGNC:60654
Mus musculus	CDC34	MGD	MGI:102657
Bos taurus	CDC34	VGNC	VGNC:27066
Rattus norvegicus	CDC34	RGD	RGD:1305411
Canis familiaris	CDC34	VGNC	VGNC:38993
Macaca mulatta	CDC34	VGNC	VGNC:108493
Others	CDC34	NCBI

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