CUL1 - cullin 1 Gene

Homo sapiens

Gene ID: 8454 | Gene type: protein coding

About CUL1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:148,697,756-148,801,110 (from NCBI)

This gene has 17 transcripts (splice variants), 249 orthologues and 7 paralogues. Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin Ligase complex and SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL1 Products(6)

mRNA	Protein	Name
NM_001370660.1	NP_001357589.1	cullin-1
NM_001370661.1	NP_001357590.1	cullin-1
NM_001370662.1	NP_001357591.1	cullin-1
NM_001370663.1	NP_001357592.1	cullin-1
NM_001370664.1	NP_001357593.1	cullin-1
NM_003592.3	NP_003583.2	cullin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11961546	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	10644755	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	11961546	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11961546	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10644755	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10644755	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	15145941	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15103331	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Parkin-FBXW7-Cul1 ubiquitin ligase complex	IPI IPI: Inferred from physical interaction	12628165	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	11956208	GOA
part of cullin-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	22405651	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19617556	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL1 Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
776 a.a.

Protein Preferred Names

Protein Names

cullin-1

CUL-1

CUL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CUL1	Q13616	UBE2M	Homo sapiens	P61081	Enzymatic Study	17914462
Intra	CUL1	Q13616	UBE2M	Homo sapiens	P61081	X-Ray Diffraction	24949976
Intra	CUL1	Q13616	CCNY	Homo sapiens	Q8ND76	Anti Tag CoIP	24794231
Cross	CUL1	Q13616	UBC12	Saccharomyces cerevisiae	P52491	Crosslink	21765416
Intra	CUL1	Q13616	FBXO3	Homo sapiens	Q9UK99	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	FBXO3	Homo sapiens	Q9UK99	TAP	21145461
Intra	CUL1	Q13616	FBXO22	Homo sapiens	Q8NEZ5	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	FBXO22	Homo sapiens	Q8NEZ5	Anti Tag CoIP	21145461
Intra	CUL1	Q13616	FBXO17	Homo sapiens	Q96EF6	TAP	21145461
Intra	CUL1	Q13616	FBXO17	Homo sapiens	Q96EF6	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	ARIH1	Homo sapiens	Q9Y4X5	TAP	21145461
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	CoIP	12609982
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	CoIP	14603323
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	TAP	21145461
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	17318178
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Tag CoIP	21145461
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	CoIP	12609982
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	17290223
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	14685242
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	TAP	21145461
Intra	CUL1	Q13616	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	CUL1	Q13616	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL1	Q13616	YBX1	Homo sapiens	P67809	TAP	21145461
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	CoIP	14603323
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	PLA	25241761
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	CoIP	10644755
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	TAP	21145461
Intra	CUL1	Q13616	FBXW7	Homo sapiens	Q969H0	CoIP	14603323
Intra	CUL1	Q13616	FBXW7	Homo sapiens	Q969H0	TAP	21145461
Intra	CUL1	Q13616	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
Intra	CUL1	Q13616	FBXO6	Homo sapiens	Q9NRD1	Anti Tag CoIP	23108047
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Solution Sedimentation	21765416
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	SAXS	18805092
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	X-Ray Diffraction	11961546
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Pull Down	20399188
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Crosslink	18805092
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	GMS	20399188
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	X-Ray Diffraction	24949976
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Pull Down	11961546
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	X-Ray Diffraction	21765416
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	CoIP	12609982
Intra	CUL1	Q13616	CAND1	Homo sapiens	Q86VP6	CoIP	12609982
Intra	CUL1	Q13616	CAND1	Homo sapiens	Q86VP6	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	CAND1	Homo sapiens	Q86VP6	Pull Down	16861300
Intra	CUL1	Q13616	SKP2	Homo sapiens	Q13309	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	SKP2	Homo sapiens	Q13309	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	SKP2	Homo sapiens	Q13309	TAP	21145461
Intra	CUL1	Q13616	CDKN1B	Homo sapiens	P46527	Pull Down	11961546
Cross	CUL1	Q13616	Fbxl21	Mus musculus	Q8BFZ4	BiFC	23452855
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Comigration in SDS	21765416
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	TAP	21145461
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Comigration in SDS	18723677
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	X-Ray Diffraction	24949976
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	18723677
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	SAXS	18805092
Intra	CUL1	Q13616	FBXO33	Homo sapiens	Q7Z6M2	TAP	21145461
Intra	CUL1	Q13616	FBXW2	Homo sapiens	Q9UKT8	Anti Tag CoIP	23108047
Intra	CUL1	Q13616	FBXW2	Homo sapiens	Q9UKT8	TAP	21145461
Intra	CUL1	Q13616	FBXW2	Homo sapiens	Q9UKT8	CoIP	14603323
Intra	CUL1	Q13616	FBXO4	Homo sapiens	Q9UKT5	Anti Tag CoIP	23108047
Intra	CUL1	Q13616	CDC34	Homo sapiens	P49427	Crosslink	19945379
Cross	CUL1	Q13616	m005R	Myxoma virus	Q83730	Anti Tag CoIP	16051867

Cross: Cross-species interaction Intra: Intraspecies interaction

CUL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82633	Cullin 1 Antibody (YA2378)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Vaccinia

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Invasive Bladder Transitional Cell Carcinoma

Invasive Bladder Urothelial Carcinoma

Infiltrating Bladder Urothelial Carcinoma

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112134	CSN5i-3	Inhibitor	99.95%	Unkown
HY-148602	KH-4-43	Inhibitor	99.99%	Unkown
HY-159601	CSN5-IN-1	Inhibitor	/	Unkown
HY-RS03359	CUL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CUL1	VGNC	VGNC:71565
Felis catus	CUL1	VGNC	VGNC:61282
Mus musculus	CUL1	MGD	MGI:1349658
Canis familiaris	CUL1	VGNC	VGNC:39728
Bos taurus	CUL1	VGNC	VGNC:55747
Rattus norvegicus	CUL1	RGD	RGD:1308157
Others	CUL1	NCBI

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