REC8 - REC8 meiotic recombination protein Gene

Homo sapiens

Also known as Rec8p; REC8L1; HR21spB

Gene ID: 9985 | Gene type: protein coding

About REC8

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,172,080-24,180,923 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 158 orthologues and 2 paralogues. Broad expression in gall bladder (RPKM 12.4), testis (RPKM 11.2) and 23 other tissues.

Summary

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

REC8 Products(2)

mRNA	Protein	Name
NM_001048205.2	NP_001041670.1	meiotic recombination protein REC8 homolog
NM_005132.3	NP_005123.2	meiotic recombination protein REC8 homolog

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REC8 Protein Structure

Rad21_Rec8_N

Rad21_Rec8

0
100
200
300
400
500
546 a.a.

Protein Preferred Names

Protein Names

meiotic recombination protein REC8 homolog

REC8 homolog

REC8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	REC8	O95072	BAG2	Homo sapiens	O95816	Lumier	25036637
Intra	REC8	O95072	BAG2	Homo sapiens	O95816	TAP	24981860
Intra	REC8	O95072	STUB1	Homo sapiens	Q9UNE7	TAP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Hereditary Spastic Paraplegia 56

Autosomal Recessive Spastic Paraplegia Type 56	Spg56
Autosomal Recessive Spastic Paraplegia 56

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11808	REC8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	REC8	VGNC	VGNC:45456
Rattus norvegicus	REC8	RGD	RGD:1309376
Mus musculus	REC8	MGD	MGI:1929645
Felis catus	REC8	VGNC	VGNC:64560
Macaca mulatta	REC8	VGNC	VGNC:76746
Bos taurus	REC8	VGNC	VGNC:33846

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