GGGDTDTC-Mc-vc-PAB-MMAE

Name: GGGDTDTC-Mc-vc-PAB-MMAE
Brand: MedChemExpress
SKU: HY-153428
Rating: 4.5 (1 reviews)

Cat. No.: HY-153428 Purity: 99.75%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

GGGDTDTC-Mc-vc-PAB-MMAE is a Drug-Linker Conjugate for ADC, containing a tubulin inhibitor Monomethyl auristatin E (MMAE, HY-15162).

For research use only. We do not sell to patients.

GGGDTDTC-Mc-vc-PAB-MMAE Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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View All Isoforms

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Biological Activity
Purity & Documentation
References
Customer Review

Description

GGGDTDTC-Mc-vc-PAB-MMAE is a Drug-Linker Conjugate for ADC, containing a tubulin inhibitor Monomethyl auristatin E (MMAE, HY-15162)^[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2040.34

Formula

C₉₃H₁₄₆N₂₀O₂₉S

Appearance

Solid

Color

White to off-white

SMILES

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(CCCCCN4C(C(SC[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC(CNC(CNC(CN)=O)=O)=O)=O)=O)=O)=O)CC4=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (98.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4901 mL	2.4506 mL	4.9011 mL
5 mM	0.0980 mL	0.4901 mL	0.9802 mL
10 mM	0.0490 mL	0.2451 mL	0.4901 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (251 KB) HNMR (553 KB) RP-HPLC (267 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Zhao YJ, et al. Nanobody drug conjugate with high activity and application of GALA polypeptide in antibody drug conjugate. China, CN112807444 A. 2021-05-18.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.4901 mL	2.4506 mL	4.9011 mL	12.2529 mL
	5 mM	0.0980 mL	0.4901 mL	0.9802 mL	2.4506 mL
	10 mM	0.0490 mL	0.2451 mL	0.4901 mL	1.2253 mL
	15 mM	0.0327 mL	0.1634 mL	0.3267 mL	0.8169 mL
	20 mM	0.0245 mL	0.1225 mL	0.2451 mL	0.6126 mL
	25 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.4901 mL
	30 mM	0.0163 mL	0.0817 mL	0.1634 mL	0.4084 mL
	40 mM	0.0123 mL	0.0613 mL	0.1225 mL	0.3063 mL
	50 mM	0.0098 mL	0.0490 mL	0.0980 mL	0.2451 mL
	60 mM	0.0082 mL	0.0408 mL	0.0817 mL	0.2042 mL
	80 mM	0.0061 mL	0.0306 mL	0.0613 mL	0.1532 mL