2. Immunology/Inflammation
  3. STING IFNAR Interleukin Related
  4. GHN105

GHN105 is an orally active inhibitor for STING that inhibits STING-dependent IFN-β secretion in THP-1 human monocytes with an IC50 of 4.4 μM. GHN105 reduces the IFN-β, IL-6 and CXCL10 levels in serum, and alleviates colitis in DSS (HY-116282)-induced acute colitis mouse model. GHN105 exhibits good pharmacokinetic parameters in mice with an oral bioavailability of 43% and a half-life of 1.1 hours.

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GHN105 Chemical Structure

GHN105 Chemical Structure

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GHN105 Related Antibodies

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Description

GHN105 is an orally active inhibitor for STING that inhibits STING-dependent IFN-β secretion in THP-1 human monocytes with an IC50 of 4.4 μM. GHN105 reduces the IFN-β, IL-6 and CXCL10 levels in serum, and alleviates colitis in DSS (HY-116282)-induced acute colitis mouse model. GHN105 exhibits good pharmacokinetic parameters in mice with an oral bioavailability of 43% and a half-life of 1.1 hours[1].

Molecular Weight

800.89

Formula

C41H56N2O14
SMILES

C[C@H]1[C@H](C[C@@H]([C@@]2([C@H]([C@H](CC(/C=N/OCC#C)=C\[C@H]3[C@]4([C@H]([C@@]12[H])OC(C)=O)[C@](O4)(C(O3)=O)C)OC(CCC)=O)OC(C)=O)C)OC(C)=O)OC(CCN5CCCCC5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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GHN105 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GHN105GHN 105GHN-105STINGIFNARInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptor ILTHP1colitisC57BL/6J mouseICR mouseorally activeInhibitorinhibitorinhibit

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