1. Anti-infection Immunology/Inflammation Apoptosis
  2. Complement System HIV Apoptosis
  3. Dextran sulfate sodium salt (MW 5000)

Dextran sulfate sodium salt (MW 5000)  (Synonyms: DSS (MW 5000); DXS (MW 5000))

Cat. No.: HY-116282 Assay: 99.20%
Handling Instructions Technical Support

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR).

For research use only. We do not sell to patients.

Dextran sulfate sodium salt (MW 5000) Chemical Structure

Dextran sulfate sodium salt (MW 5000) Chemical Structure

CAS No. : 9011-18-1

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 g In-stock
10 g In-stock
50 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dextran sulfate sodium salt (MW 5000)

View All HIV Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR)[1][2][3][4][5].

In Vitro

Coagulation activity:
Dextran sulfate sodium salt (MW 5000) enhances C1 inhibitor's effect on FXIa, accelerates thrombin inhibition by Antithrombin and heparin cofactor II.
Dextran sulfate sodium salt (MW 5000) (0.01-1 mg/mL) inhibits macroscopic clotting, abrogates platelet consumption and completely blocks the generation of C3a, FXIa-Antithrombin and thrombin-antithrombin when human islets came in contact with ABO-compatible blood[1].

Antiviral activity:
Dextran sulfate sodium salt (MW 5000) (25 μg/mL; 24 h) completely protected MT-4 cells from HIV-1-induced cytopathogenicity[2].

Others:
Dextran sulfate sodium salt (MW 5000) can be labeled with 2-aminopyridine (yielding pyridylamino-DSS or PA-DSS) and be used to examine its metabolism in Caco-2 cells. PA-DSS (MW 5000) (3%; 24 h) rapidly inhibits the energy metabolism of Caco-2 cells[3].
Dextran sulfate sodium salt (MW 5000) (0-25 mg/mL, 6 h) protects human myoblasts from NK cell mediated killing[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dextran sulfate sodium salt (MW 5000) (5 mg/mL, 200 μL, infused locally into the ischemic aortic segment immediately prior to reperfusion, ) reduces complement activation, thereby reducing endothelial damage following ischemia and reperfusion in an infrarenal aortic clamping model in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

5000(Average)

CAS No.
Appearance

Solid

Color

Off-white to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.20%

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dextran sulfate sodium salt (MW 5000)
Cat. No.:
HY-116282
Quantity:
MCE Japan Authorized Agent: