2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. Gitoxin

Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably.

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Gitoxin Chemical Structure

Gitoxin Chemical Structure

CAS No. : 4562-36-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Gitoxin:

Gitoxin Related Antibodies

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Description

Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
251.9 nM
Compound: 5
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 16309315]
TK-10 IC50
131.2 nM
Compound: 5
Cytotoxicity against human TK10 cells after 48 hrs by SRB assay
Cytotoxicity against human TK10 cells after 48 hrs by SRB assay
[PMID: 16309315]
UACC-62 IC50
369.4 nM
Compound: 5
Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay
Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay
[PMID: 16309315]
Molecular Weight

780.94

Formula

C41H64O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@]([C@@]([C@@]1([H])C(CO2)=CC2=O)(CC3)C)(C[C@@H]1O)[C@@](CC[C@]4([H])C[C@H]5O[C@H](O[C@@H]6C)C[C@@H]([C@@H]6O[C@H](O[C@@H]7C)C[C@@H]([C@@H]7O[C@H](O[C@@H]8C)C[C@@H]([C@@H]8O)O)O)O)([H])[C@@]3([H])[C@]4(CC5)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 8 mg/mL (10.24 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2805 mL 6.4025 mL 12.8051 mL
5 mM 0.2561 mL 1.2805 mL 2.5610 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.2805 mL 6.4025 mL 12.8051 mL 32.0127 mL
5 mM 0.2561 mL 1.2805 mL 2.5610 mL 6.4025 mL
10 mM 0.1281 mL 0.6403 mL 1.2805 mL 3.2013 mL
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Gitoxin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gitoxin4562-36-1Na+/K+ ATPaseSodium potassium pumpglucosideDigitoxinC-17βcardiacfailureInhibitorinhibitorinhibit

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