2. Membrane Transporter/Ion Channel
  3. CFTR
  4. GLPG-3221

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.

For research use only. We do not sell to patients.

GLPG-3221 Chemical Structure

GLPG-3221 Chemical Structure

CAS No. : 2222264-64-2

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GLPG-3221 Related Antibodies

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Description

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].

In Vivo

GLPG-3221 (1 mg/kg; i.v.) treatment shows the Cl and t1/2 are 0.13 L/h/kg and 3 hours, respectively[1].
GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1] 
Dosage: 1 mg/kg
Administration: i.v. administration (Pharmacokinetic Analysis)
Result: The Cl and t1/2 were 0.13 L/h/kg and 3 hours, respectively.
Molecular Weight

578.62

Formula

C30H37F3N2O6
CAS No.
SMILES

O=C(O)[C@H]1N(C([C@@H]2CCCCO2)=O)[C@@H](C3=CC=CC=C3C)[C@@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[C@@H]1C(C)(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GLPG-3221 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLPG-32212222264-64-2GLPG3221GLPG 3221CFTRCystic fibrosis transmembrane conductance regulatororalcysticfibrosisCYP3A4Inhibitorinhibitorinhibit

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