GLS1 Inhibitor-3

Cat. No.: HY-146616: FAQs
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GLS1 Inhibitor-3 (compound C147) is a potent GLS1 inhibitor with an IC₅₀ of 27.98 nM. GLS1 Inhibitor-3 shows antiproliferative activity.

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GLS1 Inhibitor-3 Chemical Structure

CAS No. : 2435781-94-3

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Description

GLS1 Inhibitor-3 (compound C147) is a potent GLS1 inhibitor with an IC₅₀ of 27.98 nM. GLS1 Inhibitor-3 shows antiproliferative activity^[1].

IC₅₀ & Target

IC₅₀: 27.98 nM (GLS1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.15 μM Compound: C147	Antiproliferative activity against human HCT-116 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 35428013]
HCT-116	IC₅₀	0.15 μM Compound: C147	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31603674]
MDA-MB-436	IC₅₀	0.18 μM Compound: C147	Antiproliferative activity against human MDA-MB-436 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-436 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 35428013]
MDA-MB-436	IC₅₀	0.18 μM Compound: C147	Antiproliferative activity against human MDA-MB-436 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-436 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31603674]

Molecular Weight

596.71

Formula

C₃₀H₃₂N₁₀O₂S

CAS No.

2435781-94-3

SMILES

CC1=CC=C(C=C1)CN2C=C(N=N2)CCC(NC3=CC=C(N=N3)CCCCC4=NN=C(S4)NC(CC5=NC=CC=C5)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu X, et al. Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles. Eur J Med Chem. 2022 Jun 5;236:114337. [Content Brief]

GLS1 Inhibitor-3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLS1 Inhibitor-32435781-94-3GlutaminaseHCT116MDA-MB-436 cellsmetabolic stabilityantiproliferativeInhibitorinhibitorinhibit

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