Glutamate-5-kinase-IN-2 

Glutamate-5-kinase-IN-2 (compound 54) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.2 µM. Glutamate-5-kinase-IN-2 shows G5K inhibition by promotes conformational changes at the L-glutamate binding site. Glutamate-5-kinase-IN-2 has the potential for the research of anti-TB agents^[1].

G5K^[1]

Glutamate-5-kinase-IN-2 (compound 54) (40 µM) inhibits G5K activity with an I_0.5 of 33 µM at 10 mM concentration of L-Glu and ATP^[1].
Glutamate-5-kinase-IN-2 (5, 10, 20 µM) shows no relevant cytotoxicity in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

296.73

C₁₇H₁₀ClFN₂

FC1=CC=C2C3=C(NC=C3)C(C4=CC=C(Cl)C=C4)=NC2=C1

Room temperature in continental US; may vary elsewhere.

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• [1]. Panciera M, et al. Discovery of 3H-pyrrolo[2,3-c]quinolines with activity against Mycobacterium tuberculosis by allosteric inhibition of the glutamate-5-kinase enzyme. Eur J Med Chem. 2022 Mar 15;232:114206.  [Content Brief]