2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Neuronal Signaling
  3. Endogenous Metabolite iGluR
  4. Glycine-d5

Glycine-d5 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

For research use only. We do not sell to patients.

Glycine-d<sub>5</sub> Chemical Structure

Glycine-d5 Chemical Structure

CAS No. : 4896-77-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycine-d5:

Glycine-d5 Related Antibodies

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Description

Glycine-d5 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

IC50 & Target

NMDA Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycine-d5 Related Antibodies
Molecular Weight

80.10

Formula

C2D5NO2
CAS No.
Unlabeled CAS

56-40-6
Appearance

Solid

Color

Light yellow to yellow

SMILES

[2H]N([2H])C([2H])([2H])C(O[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 125 mg/mL (1560.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 12.4844 mL 62.4220 mL 124.8439 mL
5 mM 2.4969 mL 12.4844 mL 24.9688 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 12.4844 mL 62.4220 mL 124.8439 mL 312.1099 mL
5 mM 2.4969 mL 12.4844 mL 24.9688 mL 62.4220 mL
10 mM 1.2484 mL 6.2422 mL 12.4844 mL 31.2110 mL
15 mM 0.8323 mL 4.1615 mL 8.3229 mL 20.8073 mL
20 mM 0.6242 mL 3.1211 mL 6.2422 mL 15.6055 mL
25 mM 0.4994 mL 2.4969 mL 4.9938 mL 12.4844 mL
30 mM 0.4161 mL 2.0807 mL 4.1615 mL 10.4037 mL
40 mM 0.3121 mL 1.5605 mL 3.1211 mL 7.8027 mL
50 mM 0.2497 mL 1.2484 mL 2.4969 mL 6.2422 mL
60 mM 0.2081 mL 1.0404 mL 2.0807 mL 5.2018 mL
80 mM 0.1561 mL 0.7803 mL 1.5605 mL 3.9014 mL
100 mM 0.1248 mL 0.6242 mL 1.2484 mL 3.1211 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glycine-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycine-d54896-77-9Endogenous MetaboliteiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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