2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. GNE-431

GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases.

For research use only. We do not sell to patients.

GNE-431 Chemical Structure

GNE-431 Chemical Structure

CAS No. : 1433820-83-7

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GNE-431 Related Antibodies

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Description

GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases[1][2].

Molecular Weight

564.64

Formula

C30H32N10O2
CAS No.
SMILES

O=C1N(C2=NC=CC(C3=NN4C(C(NC5=NN6C(CN(C)CC6)=C5)=C3)=NC=C4)=C2CO)CCN7C1=CC8=C7CCCC8
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GNE-431 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNE-4311433820-83-7GNE431GNE 431BtkBruton tyrosine kinasepan-BTKC481RT474IT474Mhaematological disordersautoimmune diseasesInhibitorinhibitorinhibit

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