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  6. Gochnatiolide A

Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines.

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Gochnatiolide A Chemical Structure

Gochnatiolide A Chemical Structure

CAS No. : 87606-12-0

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Based on 1 publication(s) in Google Scholar

Gochnatiolide A Related Antibodies

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  • Biological Activity

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Description

Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines[1][2].

Cellular Effect
Cell Line Type Value Description References
C6 IC50
1.2 μM
Compound: 4
Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
[PMID: 34496568]
HCCLM3 IC50
> 10 μM
Compound: 4
Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
[PMID: 34496568]
HeLa IC50
2.8 μM
Compound: 4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
[PMID: 34496568]
Huh-7 IC50
2.5 μM
Compound: 4
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
[PMID: 34496568]
PANC-1 IC50
2.2 μM
Compound: 4
Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
[PMID: 34496568]
In Vitro

Gochnatiolide A (0.25-250 μg/mL; 48 h) inhibits cell growth, with values of TGI (total growth inhibition) of 0.42, 0.49, 0.70, 1.09, 1.69, 4.66, 5.42, 6.63, 54.73, 13.13, and 114.87 μg/mL for 786.0, UACC-62, NCI-ADR/RES, U251, MCF-7, NCI-H460, HT-29, PC-3, OVCAR-3, VERO, and K562 cells, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gochnatiolide A Related Antibodies
Molecular Weight

502.56

Formula

C30H30O7
CAS No.
SMILES

O=C1[C@]2([C@]3([H])[C@]4([H])[C@](CCC([C@]3([H])C1)=C)([H])C(C(O4)=O)=C)C5=C6[C@]([C@]7([H])[C@@](C(C(O7)=O)=C)([H])CC[C@@]6(CC2)O)([H])C(C5=O)=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gochnatiolide A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gochnatiolide A87606-12-0OthersAinsliaea henryiantiproliferativekidneymelanomaovarian-resistantgliomaInhibitorinhibitorinhibit

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HY-N11108
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