Goserelin EP Impurity E

Cat. No.: HY-P4454: FAQs
Data Sheet Handling Instructions

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Goserelin EP Impurity E is the impurity of Goserelin (HY-13673).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Goserelin EP Impurity E Chemical Structure

CAS No. : 147688-42-4

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Biological Activity
Purity & Documentation
References
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Description

Goserelin EP Impurity E is the impurity of Goserelin (HY-13673)^[1].

Molecular Weight

1226.39

Formula

C₅₈H₈₃N₁₇O₁₃

CAS No.

147688-42-4

Sequence

{Pyr}-His-Trp-Ser-Tyr-{d-Ser(tBu)}-Leu-Arg-Pro-{NHNH2}

Sequence Shortening

{Pyr}-HWSY-{d-Ser(tBu)}-LRP-{NHNH2}

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kripa S. Srivastava, et al. Solid phase peptide synthesis process for the production of goserelin. Patent WO2010141276A1.