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Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer.

For research use only. We do not sell to patients.

Gossypolone Chemical Structure

Gossypolone Chemical Structure

CAS No. : 4547-72-2

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Based on 1 publication(s) in Google Scholar

Gossypolone Related Antibodies

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Description

Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer[1].

IC50 & Target

Musashi-1[1]
Cellular Effect
Cell Line Type Value Description References
HeLa IC50
23.3 μM
Compound: 13, gossypolone
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 19447525]
U-87MG ATCC IC50
26.1 μM
Compound: 13, gossypolone
Anticancer activity against human U87 cells after 48 hrs by MTT assay
Anticancer activity against human U87 cells after 48 hrs by MTT assay
[PMID: 19447525]
Molecular Weight

546.52

Formula

C30H26O10
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=CC1=C(C(O)=C(C2=C1C(C(C(C3=O)=C(C(C4=C3C(C=O)=C(C(O)=C4C(C)C)O)=O)C)=C(C2=O)C)=O)C(C)C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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Gossypolone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gossypolone4547-72-2OthersHCT-116Colon cancerMusashiRNA-binding proteinInhibitorinhibitorinhibit

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