Gp(2′-5′)Ap sodium (Synonyms: Gp(2′-5′)Ap(3′) sodium; 2'5'-GpAp sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium)

Cat. No.: HY-159857 Purity: 98.88%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

For research use only. We do not sell to patients.

Gp(2′-5′)Ap sodium Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

758.37

Formula

C₂₀H₂₃N₁₀Na₃O₁₄P₂

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](OP(OC[C@@H]2[C@@H](OP(O[Na])(O[Na])=O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)(O[Na])=O)[C@H](N5C(N=C(N)NC6=O)=C6N=C5)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (164.83 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3186 mL	6.5931 mL	13.1862 mL
5 mM	0.2637 mL	1.3186 mL	2.6372 mL
10 mM	0.1319 mL	0.6593 mL	1.3186 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.88%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (265 KB) HNMR (307 KB) CNMR (246 KB) RP-HPLC (261 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Dey RJ, Dey B, Zheng Y, et al. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017;13(2):210-217. [Content Brief]

[2]. Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498(7454):380-384. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3186 mL	6.5931 mL	13.1862 mL	32.9654 mL
	5 mM	0.2637 mL	1.3186 mL	2.6372 mL	6.5931 mL
	10 mM	0.1319 mL	0.6593 mL	1.3186 mL	3.2965 mL
	15 mM	0.0879 mL	0.4395 mL	0.8791 mL	2.1977 mL
	20 mM	0.0659 mL	0.3297 mL	0.6593 mL	1.6483 mL
	25 mM	0.0527 mL	0.2637 mL	0.5274 mL	1.3186 mL
	30 mM	0.0440 mL	0.2198 mL	0.4395 mL	1.0988 mL
	40 mM	0.0330 mL	0.1648 mL	0.3297 mL	0.8241 mL
	50 mM	0.0264 mL	0.1319 mL	0.2637 mL	0.6593 mL
	60 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5494 mL
	80 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.4121 mL
	100 mM	0.0132 mL	0.0659 mL	0.1319 mL	0.3297 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Gp(2′-5′)Ap sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gp(2′-5′)ApGp(2′-5′)Ap(3′)2'5'-GpApGuanylyl-(2′→5′)-3′-adenylic acidOthersInhibitorinhibitorinhibit

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Gp(2′-5′)Ap sodium (Synonyms: Gp(2′-5′)Ap(3′) sodium; 2'5'-GpAp sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium)

Gp(2′-5′)Ap sodium Related Antibodies

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Biological Activity

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References

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