2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. GPS1573

GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R.

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GPS1573 Chemical Structure

GPS1573 Chemical Structure

CAS No. : 2445822-54-6

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GPS1573 Related Antibodies

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Description

GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R[1].

Molecular Weight

1788.20

Formula

C86H138N28O14
CAS No.
Sequence

{Nle}-Pro-{d-Phe}-Arg-{d-Trp}-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2
Sequence Shortening

{Nle}-P-{d-Phe}-R-{d-Trp}-FKAVGKKRR-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPS1573 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPS15732445822-54-6GPS 1573GPS-1573Melanocortin ReceptorMC ReceptorAntagonistnon-competitivehighly selectiveCushing diseaseMC2RInhibitorinhibitorinhibit

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