GPX4-IN-14 

GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects^[1].

GPX4-IN-14 (100 μM, 30 min) has good free radical scavenging activity with a maximum scavenging rate of 72.52%^[1].
GPX4-IN-14 has anti-tumor proliferation activity in SW480, HCT116, HepG2, MCF-7 cells with IC₅₀ of 5.61 μM, 6.59 μM, 18.23 μM, 9.73 μM, and IC₅₀ of LO2 is 11.64 μM^[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) inhibits the GPX4 pathway in HCT116, induces the accumulation of intracellular ROS and lipid ROS in a dose-dependent manner, leading to ferroptosis and inhibiting mitochondrial membrane potential^[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) induces a dose-dependent increase in intracellular iron levels in HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

572.55

C₂₆H₃₉NO₈Se

O=C(CCC(OCCCCCC[Se]C#N)=O)O[C@H]1[C@H](C)[C@@]2([H])[C@]3([C@]4([H])[C@H](C)CC2)[C@](O[C@@](OO3)(C)CC4)([H])O1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Meilin Ren, et al. Design, synthesis and biological evaluation of artesunate-Se derivatives as anticancer agents by inducing GPX4-mediated ferroptosis. Bioorg Chem. 2024 Nov:152:107733.  [Content Brief]