2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
  4. GPX4-IN-14

GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects.

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GPX4-IN-14 Chemical Structure

GPX4-IN-14 Chemical Structure

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GPX4-IN-14 Related Antibodies

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Description

GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects[1].

In Vitro

GPX4-IN-14 (100 μM, 30 min) has good free radical scavenging activity with a maximum scavenging rate of 72.52%[1].
GPX4-IN-14 has anti-tumor proliferation activity in SW480, HCT116, HepG2, MCF-7 cells with IC50 of 5.61 μM, 6.59 μM, 18.23 μM, 9.73 μM, and IC50 of LO2 is 11.64 μM[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) inhibits the GPX4 pathway in HCT116, induces the accumulation of intracellular ROS and lipid ROS in a dose-dependent manner, leading to ferroptosis and inhibiting mitochondrial membrane potential[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) induces a dose-dependent increase in intracellular iron levels in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4-IN-14 Related Antibodies

Immunofluorescence[1]

Cell Line: HCT116
Concentration: 3.3, 6.6, 13.2 μM
Incubation Time: 24 h
Result: Induced significant accumulation of ROS.
Depolarized mitochondrial membrane potential (MMP) in a dose-dependent manner.
Increased lipid ROS levels in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 3.3, 6.6, 13.2 μM
Incubation Time: 24 h
Result: Inhibited the expression level of GXP4 and increased the expression of FTH1.

Real Time qPCR[1]

Cell Line: HCT116
Concentration: 3.3, 6.6, 13.2 μM
Incubation Time: 24 h
Result: Inhibited GXP4 expression level.
Molecular Weight

572.55

Formula

C26H39NO8Se
SMILES

O=C(CCC(OCCCCCC[Se]C#N)=O)O[C@H]1[C@H](C)[C@@]2([H])[C@]3([C@]4([H])[C@H](C)CC2)[C@](O[C@@](OO3)(C)CC4)([H])O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPX4-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-14FerroptosisGlutathione PeroxidaseReactive Oxygen SpeciesHCT116ROSInhibition of tumor proliferationInhibitorinhibitorinhibit

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