1. Apoptosis
  2. Bcl-2 Family
  3. GQN-B37-E

GQN-B37-E is a potent selective binder and inhibitor of MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range (Ki = 0.6 μM) without apparent binding to BCL-2 or BCL-XL.

For research use only. We do not sell to patients.

GQN-B37-E Chemical Structure

GQN-B37-E Chemical Structure

CAS No. : 2982663-28-3

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Description

GQN-B37-E is a potent selective binder and inhibitor of MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range (Ki = 0.6 μM) without apparent binding to BCL-2 or BCL-XL[1].

IC50 & Target

Mcl-1

0.6 μM (Ki)

Molecular Weight

526.97

Formula

C29H23ClN4O4

CAS No.
SMILES

O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC(/C=C/C3=CN(C4=CC=CC(Cl)=C4)N=C3C5=CC=C(O)C=C5)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GQN-B37-E
Cat. No.:
HY-161732
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