Griffipavixanthone (Synonyms: (+)-Griffipavixanthone)

Cat. No.: HY-N3974: FAQs
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Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC₅₀: 4.58 mM).

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Griffipavixanthone Chemical Structure

CAS No. : 219649-95-3

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	> 10 μM Compound: 16	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 24960143]
L02	IC₅₀	> 10 μM Compound: 16	Cytotoxicity against human HL7702 cells by MTT assay Cytotoxicity against human HL7702 cells by MTT assay	[PMID: 24960143]
MCF7	IC₅₀	> 10 μM Compound: 16	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 24960143]
MDA-MB-231	IC₅₀	> 10 μM Compound: 16	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 24960143]

Molecular Weight

652.60

Formula

C₃₆H₂₈O₁₂

CAS No.

219649-95-3

SMILES

OC1=C(O)C(OC2=CC(O)=CC(O)=C2C3=O)=C3C4=C1[C@@H](C5=C6C(OC7=CC(O)=CC(O)=C7C6=O)=C(C(O)=C5)O)[C@@]8([H])[C@]4([H])C=C(C)CC8(C)C

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618. [Content Brief]

[2]. Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31. [Content Brief]

[3]. Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197. [Content Brief]

Griffipavixanthone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Griffipavixanthone219649-95-3(+)-GriffipavixanthoneApoptosisH520anti-cancerNSCLCbreast cancerInhibitorinhibitorinhibit

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