2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. GRK5-IN-4

GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research. GRK5-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

GRK5-IN-4 Chemical Structure

GRK5-IN-4 Chemical Structure

CAS No. : 2410794-89-5

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GRK5-IN-4 Related Antibodies

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Description

GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research[1]. GRK5-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 1.1 ± 0.4 μM (GRK5), 1.8 ± 2 μM (GRK6), >100 μM (GRK2)[1]
In Vitro

GRK5-IN-4 (Compound 16d) (0-4 h) displays a marked increase in apparent potency as a function of time[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GRK5-IN-4 Related Antibodies
Molecular Weight

483.52

Formula

C26H25N7O3
CAS No.
SMILES

O=C(NCC1=CC=C(C(OC)=C1)NC2=NC(NC3=C(C(NC)=O)C=CC=C3)=C4C=CNC4=N2)C#CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GRK5-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRK5-IN-42410794-89-5CCG-265328CCG265328CCG 265328G Protein-coupled Receptor Kinase (GRK)Pyrrolopyrimidinecovalent inhibitorkinase inhibitorGPCR kinaseheart failureInhibitorinhibitorinhibit

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