2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GS87

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research.

For research use only. We do not sell to patients.

GS87 Chemical Structure

GS87 Chemical Structure

CAS No. : 919936-70-2

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Based on 1 publication(s) in Google Scholar

GS87 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

IC50 & Target[1]

GSK3α

415 nM (IC50)

GSK3β

521 nM (IC50)

Molecular Weight

337.36

Formula

C16H11N5O2S
CAS No.
SMILES

C1(C2=NN=C(SCC3=NC(C4=CC=CC=C4)=NO3)O2)=CC=NC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GS87 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS87919936-70-2GS 87GS-87GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3GSK3GSK3αGSK3βdifferentiationAMLMAPKInhibitorinhibitorinhibit

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