2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 8

GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation.

For research use only. We do not sell to patients.

GSK-3β inhibitor 8 Chemical Structure

GSK-3β inhibitor 8 Chemical Structure

CAS No. : 1139875-74-3

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GSK-3β inhibitor 8 Related Antibodies

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Description

GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].

IC50 & Target[1]

GSK-3β

64 nM (IC50)

In Vitro

GSK-3β inhibitor 8 (compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. And GSK-3β inhibitor 8 (2 μM; 72 h) increases the replicating R7T1 β cells about 2-fold[1].
GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces the activation of Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM[1].
GSK-3β inhibitor 8 (2 μM; 72 h) stimulates the translocation of β-catenin into the nucleus in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-3β inhibitor 8 Related Antibodies
Molecular Weight

413.92

Formula

C20H20ClN5OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NC2=NC=CC(C3=CC=CS3)=N2)C=C1Cl)N4CCN(C)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (241.59 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4159 mL 12.0796 mL 24.1593 mL
5 mM 0.4832 mL 2.4159 mL 4.8319 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4159 mL 12.0796 mL 24.1593 mL 60.3981 mL
5 mM 0.4832 mL 2.4159 mL 4.8319 mL 12.0796 mL
10 mM 0.2416 mL 1.2080 mL 2.4159 mL 6.0398 mL
15 mM 0.1611 mL 0.8053 mL 1.6106 mL 4.0265 mL
20 mM 0.1208 mL 0.6040 mL 1.2080 mL 3.0199 mL
25 mM 0.0966 mL 0.4832 mL 0.9664 mL 2.4159 mL
30 mM 0.0805 mL 0.4027 mL 0.8053 mL 2.0133 mL
40 mM 0.0604 mL 0.3020 mL 0.6040 mL 1.5100 mL
50 mM 0.0483 mL 0.2416 mL 0.4832 mL 1.2080 mL
60 mM 0.0403 mL 0.2013 mL 0.4027 mL 1.0066 mL
80 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7550 mL
100 mM 0.0242 mL 0.1208 mL 0.2416 mL 0.6040 mL
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GSK-3β inhibitor 8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 81139875-74-3GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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