2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) IFNAR TNF Receptor
  4. GSK2245035 maleate

GSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma.

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GSK2245035 maleate Chemical Structure

GSK2245035 maleate Chemical Structure

CAS No. : 1325212-97-2

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GSK2245035 maleate Related Antibodies

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

GSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma[1].

Molecular Weight

506.60

Formula

C24H38N6O6
CAS No.
SMILES

OC(/C=C\C(O)=O)=O.O=C(N(C1=NC(O[C@@H](C)CCC)=N2)CCCCCN3CCCCC3)NC1=C2N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK2245035 maleate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK22450351325212-97-2GSK 2245035GSK-2245035Toll-like Receptor (TLR)IFNARTNF ReceptorInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRintranasalpreferentialType-1interferonallergen-inducedTh2cytokineperipheralbloodasthmaInhibitorinhibitorinhibit

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