GW 590735 sodium

Cat. No.: HY-106278A: FAQs
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GW 590735 sodium is a potent and selective PPARα agonist with activity in regulating lipid metabolism. GW 590735 significantly increased high-density lipoprotein (HDL) cholesterol, decreased low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol, and significantly reduced triglycerides. The maximum increases in HDL cholesterol for GW 590735 were 37%, 53% and 84%, respectively, compared with bezafibrate, torcetrapib and GW 590735.

For research use only. We do not sell to patients.

GW 590735 sodium Chemical Structure

CAS No. : 343322-50-9

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description	GW 590735 sodium is a potent and selective PPARα agonist with activity in regulating lipid metabolism. GW 590735 significantly increased high-density lipoprotein (HDL) cholesterol, decreased low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol, and significantly reduced triglycerides. The maximum increases in HDL cholesterol for GW 590735 were 37%, 53% and 84%, respectively, compared with bezafibrate, torcetrapib and GW 590735^[1].
Molecular Weight	500.47
Formula	C₂₃H₂₀F₃N₂NaO₄S
CAS No.	343322-50-9
SMILES	O=C(C(C)(C)OC1=CC=C(CNC(C2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=O)C=C1)O[Na]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Sierra ML, et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem. 2007;50(4):685-695. [Content Brief] [2]. Gateways to clinical trials. July-August 2008 [Content Brief]

GW 590735 sodium Related Classifications

Metabolic Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 590735343322-50-9GW590735GW-590735PPARPeroxisome proliferator-activated receptorsdyslipidemialipidimbalanceHDLctriglyceridesLDLcInhibitorinhibitorinhibit

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