2. PROTAC Stem Cell/Wnt Apoptosis
  3. PROTACs YAP c-Myc
  4. H122

H122 is a PROTAC degrader for TEAD that degrades TEAD1 with a DC50 of 3 nM, and exhibits good affinity to TEAD2, TEAD3, and TEAD4 with Ki of 2.0, 3.6 and 1.6 nM. H122 downregulates the expression of Myc. H122 inhibits the cell growth of MSTO-211H and NCI-H226 with IC50 of 21.3 nM and 0.6 nM, and exhibits antitumor efficacy in mouse models. (Pink: ligand for target protein (HY-151525); Black: linker (HY-W573128); Blue: ligand for E3 ligase Cereblon (HY-W087383))

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H122 Chemical Structure

H122 Chemical Structure

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H122 Related Antibodies

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YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

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Description

H122 is a PROTAC degrader for TEAD that degrades TEAD1 with a DC50 of 3 nM, and exhibits good affinity to TEAD2, TEAD3, and TEAD4 with Ki of 2.0, 3.6 and 1.6 nM. H122 downregulates the expression of Myc. H122 inhibits the cell growth of MSTO-211H and NCI-H226 with IC50 of 21.3 nM and 0.6 nM, and exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-151525); Black: linker (HY-W573128); Blue: ligand for E3 ligase Cereblon (HY-W087383))

Molecular Weight

838.32

Formula

C45H45ClFN5O8
SMILES

COCCOC1=C([C@@]([C@@]2=C(C=CC3=C2C[C@@](C4=CC=CC=C4)(O3)CNCCC5CCN(CC5)C6=CC=C(C7=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)Cl)=C(C=C1)C(N)=O)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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H122 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H122H 122H-122PROTACsYAPc-MycYes-associated proteinMycMSTO-211HNCI-H226ICR mouseInhibitorinhibitorinhibit

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