2. Immunology/Inflammation
  3. PGE synthase
  4. hPGDS-IN-1

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.

For research use only. We do not sell to patients.

hPGDS-IN-1 Chemical Structure

hPGDS-IN-1 Chemical Structure

CAS No. : 1234708-04-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 220 In-stock
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid
1 mg USD 90 In-stock
5 mg USD 200 In-stock
10 mg USD 320 In-stock
50 mg USD 900 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

hPGDS-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE hPGDS-IN-1

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  • Purity & Documentation

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Description

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay. IC50 value: 12 nM Target: hPGDS The detailed information please refer to WO2011044307A1 and WO2010080563A2

Molecular Weight

416.43

Formula

C22H20N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C)(C)C1=NC(C2=CC(CNC(C(C=N3)=CN=C3C4=CC=CC=N4)=O)=CC=C2)=NO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (72.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4014 mL 12.0068 mL 24.0136 mL
5 mM 0.4803 mL 2.4014 mL 4.8027 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.92%

COA (246 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4014 mL 12.0068 mL 24.0136 mL 60.0341 mL
5 mM 0.4803 mL 2.4014 mL 4.8027 mL 12.0068 mL
10 mM 0.2401 mL 1.2007 mL 2.4014 mL 6.0034 mL
15 mM 0.1601 mL 0.8005 mL 1.6009 mL 4.0023 mL
20 mM 0.1201 mL 0.6003 mL 1.2007 mL 3.0017 mL
25 mM 0.0961 mL 0.4803 mL 0.9605 mL 2.4014 mL
30 mM 0.0800 mL 0.4002 mL 0.8005 mL 2.0011 mL
40 mM 0.0600 mL 0.3002 mL 0.6003 mL 1.5009 mL
50 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2007 mL
60 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0006 mL
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hPGDS-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hPGDS-IN-11234708-04-3PGE synthaseProstaglandin E synthaseInhibitorinhibitorinhibit

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